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TAA8A_RAT
ID   TAA8A_RAT               Reviewed;         344 AA.
AC   Q923X9;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Trace amine-associated receptor 8a;
DE            Short=TaR-8a;
DE            Short=Trace amine receptor 8a;
DE   AltName: Full=Trace amine receptor 11;
DE            Short=TaR-11;
GN   Name=Taar8a; Synonyms=Ta11, Tar11, Trar11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11459929; DOI=10.1073/pnas.151105198;
RA   Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA   Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA   Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA   Gerald C.;
RT   "Trace amines: identification of a family of mammalian G protein-coupled
RT   receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC   -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC       amines are biogenic amines present in very low levels in mammalian
CC       tissues. Although some trace amines have clearly defined roles as
CC       neurotransmitters in invertebrates, the extent to which they function
CC       as true neurotransmitters in vertebrates has remained speculative.
CC       Trace amines are likely to be involved in a variety of physiological
CC       functions that have yet to be fully understood.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK71250.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF380199; AAK71250.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_783189.1; NM_175599.1.
DR   RefSeq; XP_017445356.1; XM_017589867.1.
DR   RefSeq; XP_017445965.1; XM_017590476.1.
DR   AlphaFoldDB; Q923X9; -.
DR   SMR; Q923X9; -.
DR   STRING; 10116.ENSRNOP00000040109; -.
DR   GlyGen; Q923X9; 2 sites.
DR   PaxDb; Q923X9; -.
DR   GeneID; 319104; -.
DR   KEGG; rno:319104; -.
DR   CTD; 215859; -.
DR   RGD; 631391; Taar8a.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; Q923X9; -.
DR   OrthoDB; 995146at2759; -.
DR   PhylomeDB; Q923X9; -.
DR   TreeFam; TF343107; -.
DR   Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR   PRO; PR:Q923X9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..344
FT                   /note="Trace amine-associated receptor 8a"
FT                   /id="PRO_0000070176"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..102
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..127
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..291
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..314
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..344
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   344 AA;  38065 MW;  CC75FFAC392A637A CRC64;
     MTSNFSQAPL QLCYENVNAS CIKTPYSPGL RVLLYMVFGF GAVLAVCGNL LVVISVLHFK
     QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DTFCSLHSCC DAAFCYSSLF
     HLCFISVDRY IAVTDPLVYP TKFTVSVSGI CISISWILPL VYSSAVFYTG ISATGIENLV
     SALNCVGGCQ IVVNQDWVLI DFLLFLIPTL VMIILYSKIF LVAKQQAVKI ETSISGSKGE
     SSLESHKARV AKRERKAAKT LGVTVVAFMV SWLPYTIDTL IDAFMGFITP AYVYEICCWS
     AYYNSAMNPL IYAFFYPWFR KAIKLILSGE ILKSHSSTMS LFSE
 
 
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