TAA8B_RAT
ID TAA8B_RAT Reviewed; 344 AA.
AC Q923Y3;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Trace amine-associated receptor 8b;
DE Short=TaR-8b;
DE Short=Trace amine receptor 8b;
DE AltName: Full=Trace amine receptor 7;
DE Short=TaR-7;
GN Name=Taar8b; Synonyms=Ta7, Tar7, Trar7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380195; AAK71246.1; -; Genomic_DNA.
DR RefSeq; NP_783191.1; NM_175601.1.
DR RefSeq; XP_017444799.1; XM_017589310.1.
DR RefSeq; XP_017444800.1; XM_017589311.1.
DR AlphaFoldDB; Q923Y3; -.
DR SMR; Q923Y3; -.
DR GlyGen; Q923Y3; 2 sites.
DR PRIDE; Q923Y3; -.
DR GeneID; 319106; -.
DR KEGG; rno:319106; -.
DR CTD; 382348; -.
DR RGD; 631386; Taar8b.
DR InParanoid; Q923Y3; -.
DR OrthoDB; 995146at2759; -.
DR PhylomeDB; Q923Y3; -.
DR TreeFam; TF343107; -.
DR PRO; PR:Q923Y3; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="Trace amine-associated receptor 8b"
FT /id="PRO_0000070178"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..319
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 344 AA; 38044 MW; 45C41C861E5F6408 CRC64;
MTSNFSQATL QLCYENVNAS CIKTPYSPGL RVLLYMVFGF GAVLAVCGNL LVVISVLHFK
QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DTFCSLHSCC DAAFCYSSLF
HLCFISVDRY IAVTEPLVYP TKFTMSVSGI CISISWILPL VYSSAVFYTG ISATGIENLV
SALNCVGGCQ VAINQDWVLI SFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSISGSKGE
SSLESHKARV AKRERKAAKT LGVTVMAFMV SWLPYTIDTL IDAFMGFITP AYVYEICGWI
AYYNSAMNPL IYAFFYPWFR KAIKLILSGK ILKGHSSTTS LFSE
