TAA8C_MOUSE
ID TAA8C_MOUSE Reviewed; 344 AA.
AC Q5QD05; B2RT38;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Trace amine-associated receptor 8c;
DE Short=TaR-8c;
DE Short=Trace amine receptor 8c;
DE Short=mTaar8c;
GN Name=Taar8c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Orphan olfactory receptor specific for trace amines.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium. {ECO:0000269|PubMed:16878137}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY702339; AAV70148.1; -; Genomic_DNA.
DR EMBL; BC139121; AAI39122.1; -; mRNA.
DR EMBL; BC139122; AAI39123.1; -; mRNA.
DR CCDS; CCDS23747.1; -.
DR RefSeq; NP_001010840.1; NM_001010840.2.
DR AlphaFoldDB; Q5QD05; -.
DR SMR; Q5QD05; -.
DR STRING; 10090.ENSMUSP00000133193; -.
DR GlyGen; Q5QD05; 2 sites.
DR PaxDb; Q5QD05; -.
DR PRIDE; Q5QD05; -.
DR Ensembl; ENSMUST00000170267; ENSMUSP00000133193; ENSMUSG00000100004.
DR GeneID; 494546; -.
DR KEGG; mmu:494546; -.
DR UCSC; uc007eqq.2; mouse.
DR CTD; 494546; -.
DR MGI; MGI:3527452; Taar8c.
DR VEuPathDB; HostDB:ENSMUSG00000100004; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161306; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD05; -.
DR OMA; CTSSIAN; -.
DR OrthoDB; 995146at2759; -.
DR PhylomeDB; Q5QD05; -.
DR TreeFam; TF343107; -.
DR BioGRID-ORCS; 494546; 2 hits in 38 CRISPR screens.
DR PRO; PR:Q5QD05; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD05; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="Trace amine-associated receptor 8c"
FT /id="PRO_0000070179"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 344 AA; 37890 MW; 04E2BE1B8B68A85C CRC64;
MTSNFSQPAL QLCYENTNGS CIKTPYSPGP RVILYMVYGF GAVLAVCGNL LVVISVLHFK
QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DAFCSLHSCC DVAFCYSSAL
HLCFISVDRY IAVTDPLVYP TKFTVSVSGI CISISWILPL VYSSAVFYTG ISAKGIESLV
SALNCVGGCQ VVVNQDWVLI SFLLFFIPTV VMIILYSKIF LVAKQQAVKI ETSVSGNRGE
SSSESHKARV AKRERKAAKT LGVTVVAFMV SWLPYTIDAL VDAFMGFITP AYVYEICCWS
AYYNSAMNPL IYAFFYPWFR KAIKLILSGK ILKGHSSTTN LFSE
