TAAR1_MOUSE
ID TAAR1_MOUSE Reviewed; 332 AA.
AC Q923Y8; Q05A85;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Trace amine-associated receptor 1;
DE Short=TaR-1;
DE Short=Trace amine receptor 1;
GN Name=Taar1; Synonyms=Ta1, Tar1, Trar1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Receptor for trace amines, including beta-phenylethylamine
CC (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest
CC affinity for b-PEA and p-TYR. Unresponsive to classical biogenic
CC amines, such as epinephrine and histamine and only partially activated
CC by dopamine and serotonin. Trace amines are biogenic amines present in
CC very low levels in mammalian tissues. Although some trace amines have
CC clearly defined roles as neurotransmitters in invertebrates, the extent
CC to which they function as true neurotransmitters in vertebrates has
CC remained speculative. Trace amines are likely to be involved in a
CC variety of physiological functions that have yet to be fully
CC understood. The signal transduced by this receptor is mediated by the
CC G(s)-class of G-proteins which activate adenylate cyclase.
CC {ECO:0000269|PubMed:15718104}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely distributed throughout the brain. Strongly
CC expressed in the mitral cell layer of the olfactory bulb, piriform
CC cortex, the arcuate, motor, and mesencephalic trigeminal nuclei,
CC lateral reticular and hypoglossal nuclei, cerebellar Purkinje cells,
CC and ventral horn of the spinal cord. Moderately expressed in the
CC frontal, entorhinal, and agranular cortices, the ventral pallidum,
CC thalamus, hippocampus, several hypothalamic nuclei, ambiguus, dorsal
CC raphe, and gigantocellular reticular nuclei. Weakly expressed in the
CC septum, basal ganglia, amygdala, myelencephalon, and spinal cord dorsal
CC horn. Particularly interesting is the moderate expression in several
CC monoaminergic cell groups, namely the dorsal raphe, the locus
CC coeruleus, and the ventral tegmental area.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380187; AAK71238.1; -; Genomic_DNA.
DR EMBL; BC125368; AAI25369.1; -; mRNA.
DR EMBL; BC125370; AAI25371.1; -; mRNA.
DR CCDS; CCDS23735.1; -.
DR RefSeq; NP_444435.1; NM_053205.1.
DR AlphaFoldDB; Q923Y8; -.
DR SMR; Q923Y8; -.
DR STRING; 10090.ENSMUSP00000049527; -.
DR BindingDB; Q923Y8; -.
DR ChEMBL; CHEMBL4908; -.
DR DrugCentral; Q923Y8; -.
DR GuidetoPHARMACOLOGY; 364; -.
DR GlyGen; Q923Y8; 1 site.
DR PhosphoSitePlus; Q923Y8; -.
DR PaxDb; Q923Y8; -.
DR PRIDE; Q923Y8; -.
DR Antibodypedia; 19712; 178 antibodies from 28 providers.
DR DNASU; 111174; -.
DR Ensembl; ENSMUST00000051532; ENSMUSP00000049527; ENSMUSG00000056379.
DR GeneID; 111174; -.
DR KEGG; mmu:111174; -.
DR UCSC; uc007eqd.1; mouse.
DR CTD; 134864; -.
DR MGI; MGI:2148258; Taar1.
DR VEuPathDB; HostDB:ENSMUSG00000056379; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182934; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q923Y8; -.
DR OMA; YIPGFVM; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q923Y8; -.
DR TreeFam; TF343107; -.
DR Reactome; R-MMU-375280; Amine ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 111174; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Slc7a5; mouse.
DR PRO; PR:Q923Y8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q923Y8; protein.
DR Bgee; ENSMUSG00000056379; Expressed in islet of Langerhans and 2 other tissues.
DR Genevisible; Q923Y8; MM.
DR GO; GO:0016021; C:integral component of membrane; IC:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; IDA:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0001594; F:trace-amine receptor activity; IDA:MGI.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009133; TAAR1.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01831; TRACEAMINE1R.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..332
FT /note="Trace amine-associated receptor 1"
FT /id="PRO_0000070143"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 332 AA; 37621 MW; 680BE692B1892264 CRC64;
MHLCHAITNI SHRNSDWSRE VQASLYSLMS LIILATLVGN LIVIISISHF KQLHTPTNWL
LHSMAIVDFL LGCLIMPCSM VRTVERCWYF GEILCKVHTS TDIMLSSASI FHLAFISIDR
YCAVCDPLRY KAKINISTIL VMILVSWSLP AVYAFGMIFL ELNLKGVEEL YRSQVSDLGG
CSPFFSKVSG VLAFMTSFYI PGSVMLFVYY RIYFIAKGQA RSINRTNVQV GLEGKSQAPQ
SKETKAAKTL GIMVGVFLVC WCPFFLCTVL DPFLGYVIPP SLNDALYWFG YLNSALNPMV
YAFFYPWFRR ALKMVLLGKI FQKDSSRSKL FL
