TAAR1_RAT
ID TAAR1_RAT Reviewed; 332 AA.
AC Q923Y9; Q5QD26; Q8VHQ5;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Trace amine-associated receptor 1;
DE Short=TaR-1;
DE Short=Trace amine receptor 1;
GN Name=Taar1; Synonyms=Ta1, Tar1, Trar1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-170.
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley; TISSUE=Cerebellum, and Pancreatic tumor;
RX PubMed=11723224; DOI=10.1124/mol.60.6.1181;
RA Bunzow J.R., Sonders M.S., Arttamangkul S., Harrison L.M., Zhang G.,
RA Quigley D.I., Darland T., Suchland K.L., Pasumamula S., Kennedy J.L.,
RA Olson S.B., Magenis R.E., Amara S.G., Grandy D.K.;
RT "Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid
RT diethylamide, and metabolites of the catecholamine neurotransmitters are
RT agonists of a rat trace amine receptor.";
RL Mol. Pharmacol. 60:1181-1188(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND VARIANT GLN-170.
RC STRAIN=WIST/Crl;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Receptor for trace amines, including beta-phenylethylamine
CC (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest
CC affinity for b-PEA and p-TYR. Unresponsive to classical biogenic
CC amines, such as epinephrine and histamine and only partially activated
CC by dopamine and serotonin. Trace amines are biogenic amines present in
CC very low levels in mammalian tissues. Although some trace amines have
CC clearly defined roles as neurotransmitters in invertebrates, the extent
CC to which they function as true neurotransmitters in vertebrates has
CC remained speculative. Trace amines are likely to be involved in a
CC variety of physiological functions that have yet to be fully
CC understood. The signal transduced by this receptor is mediated by the
CC G(s)-class of G-proteins which activate adenylate cyclase.
CC {ECO:0000269|PubMed:15718104}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely distributed, but in low abundance,
CC throughout the brain. Highest levels detected in the olfactory bulb,
CC nucleus accumbens/olfactory tubercle, prefrontal cortex and other
CC cortical regions, midbrain regions consisting of substantia nigra and
CC ventral tegmentum, cerebellum, and pons/medulla. Among peripheral
CC tissues, highest level observed in the liver, less expression in
CC kidney, gastrointestinal tract, spleen, pancreas, and heart.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380186; AAK71237.1; -; Genomic_DNA.
DR EMBL; AF421352; AAL65137.1; -; mRNA.
DR EMBL; AY702315; AAV70127.1; -; Genomic_DNA.
DR RefSeq; NP_599155.1; NM_134328.1.
DR AlphaFoldDB; Q923Y9; -.
DR SMR; Q923Y9; -.
DR STRING; 10116.ENSRNOP00000021510; -.
DR BindingDB; Q923Y9; -.
DR ChEMBL; CHEMBL3833; -.
DR DrugCentral; Q923Y9; -.
DR GuidetoPHARMACOLOGY; 364; -.
DR GlyGen; Q923Y9; 3 sites.
DR PhosphoSitePlus; Q923Y9; -.
DR PaxDb; Q923Y9; -.
DR GeneID; 113914; -.
DR KEGG; rno:113914; -.
DR CTD; 134864; -.
DR RGD; 621621; Taar1.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q923Y9; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q923Y9; -.
DR TreeFam; TF343107; -.
DR Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR PRO; PR:Q923Y9; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:RGD.
DR GO; GO:0001594; F:trace-amine receptor activity; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; IDA:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009133; TAAR1.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01831; TRACEAMINE1R.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..332
FT /note="Trace amine-associated receptor 1"
FT /id="PRO_0000070145"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 283
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 170
FT /note="L -> Q"
FT /evidence="ECO:0000269|PubMed:11459929,
FT ECO:0000269|PubMed:15718104"
SQ SEQUENCE 332 AA; 38021 MW; AD7F3A728C77B246 CRC64;
MHLCHNSANI SHTNSNWSRD VRASLYSLIS LIILTTLVGN LIVIISISHF KQLHTPTNWL
LHSMAVVDFL LGCLVMPYSM VRTVEHCWYF GELFCKLHTS TDIMLSSASI LHLAFISIDR
YYAVCDPLRY KAKINLAAIF VMILISWSLP AVFAFGMIFL ELNLEGVEEL YHNQVFCLRG
CFPFFSKVSG VLAFMTSFYI PGSVMLFVYY RIYFIAKGQA RSINRANLQV GLEGESRAPQ
SKETKAAKTL GIMVGVFLLC WCPFFFCMVL DPFLGYVIPP TLNDTLNWFG YLNSAFNPMV
YAFFYPWFRR ALKMVLFGKI FQKDSSRSKL FL
