TAAR2_MOUSE
ID TAAR2_MOUSE Reviewed; 339 AA.
AC Q5QD17; A6H6B2; Q80T53;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Trace amine-associated receptor 2;
DE Short=TaR-2;
DE Short=Trace amine receptor 2;
DE Short=mTaar2;
DE AltName: Full=G-protein coupled receptor 58;
GN Name=Taar2; Synonyms=Gm225, Gpr58;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-313.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Orphan olfactory receptor specific for trace amines.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium. {ECO:0000269|PubMed:16878137}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702326; AAV70136.1; -; mRNA.
DR EMBL; BC139118; AAI39119.1; -; mRNA.
DR EMBL; BC145814; AAI45815.1; -; mRNA.
DR EMBL; AY255589; AAO85101.1; -; mRNA.
DR CCDS; CCDS35869.1; -.
DR RefSeq; NP_001007267.1; NM_001007266.1.
DR AlphaFoldDB; Q5QD17; -.
DR SMR; Q5QD17; -.
DR STRING; 10090.ENSMUSP00000078137; -.
DR GlyGen; Q5QD17; 2 sites.
DR iPTMnet; Q5QD17; -.
DR PhosphoSitePlus; Q5QD17; -.
DR PaxDb; Q5QD17; -.
DR PRIDE; Q5QD17; -.
DR Antibodypedia; 19711; 105 antibodies from 25 providers.
DR DNASU; 209512; -.
DR Ensembl; ENSMUST00000079134; ENSMUSP00000078137; ENSMUSG00000059763.
DR GeneID; 209512; -.
DR KEGG; mmu:209512; -.
DR UCSC; uc007eqe.1; mouse.
DR CTD; 9287; -.
DR MGI; MGI:2685071; Taar2.
DR VEuPathDB; HostDB:ENSMUSG00000059763; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161475; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD17; -.
DR OMA; DCSEFGN; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD17; -.
DR TreeFam; TF343107; -.
DR Reactome; R-MMU-375280; Amine ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 209512; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q5QD17; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD17; protein.
DR Bgee; ENSMUSG00000059763; Expressed in morula and 6 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..339
FT /note="Trace amine-associated receptor 2"
FT /id="PRO_0000070147"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 339 AA; 38517 MW; 8F38253A3C677B20 CRC64;
MASFEAQQET FDCSEYGNGS CPENERSLGV RAAMYSLMAC AIFITIFGNL AMIISISYFK
QLHTPTNLLI LSMAVTDFLL GFTIMPYSMV RSVENCWYFG LTFCKIHYSF DLMLSITSIF
HLCSVAVDRF YAICHPLHYC TKMTIPVVRR LLLVCWSVPG AFAFGVVFSE AYADGIEGYD
ILVACSSSCP VMFNKLWGTT LFVAGFFTPS SMMVGIYGKI FAVSKKHARV IDNLPENQNN
QMRKDKKAAK TLGIVMGVFL LCWFPCFFTI LLDPFLNFST PAVLFDALTW FGYFNSTCNP
LIYGFFYPWF RRALKYILLG KIFSSHFHNT NLFTQKETE
