ID   TAAR2_RAT               Reviewed;         339 AA.
AC   Q5QD25;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Trace amine-associated receptor 2;
DE            Short=TaR-2;
DE            Short=Trace amine receptor 2;
DE   AltName: Full=G-protein coupled receptor 58;
GN   Name=Taar2; Synonyms=Gpr58;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=WIST/Crl;
RX   PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA   Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA   Hoener M.C.;
RT   "Trace amine-associated receptors form structurally and functionally
RT   distinct subfamilies of novel G protein-coupled receptors.";
RL   Genomics 85:372-385(2005).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY702316; AAV70128.1; -; mRNA.
DR   RefSeq; NP_001008512.1; NM_001008512.1.
DR   AlphaFoldDB; Q5QD25; -.
DR   SMR; Q5QD25; -.
DR   STRING; 10116.ENSRNOP00000030671; -.
DR   GlyGen; Q5QD25; 2 sites.
DR   PhosphoSitePlus; Q5QD25; -.
DR   PaxDb; Q5QD25; -.
DR   Ensembl; ENSRNOT00000035424; ENSRNOP00000030671; ENSRNOG00000025951.
DR   GeneID; 294121; -.
DR   KEGG; rno:294121; -.
DR   CTD; 9287; -.
DR   RGD; 1311240; Taar2.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000161475; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q5QD25; -.
DR   OMA; DCSEFGN; -.
DR   OrthoDB; 913195at2759; -.
DR   PhylomeDB; Q5QD25; -.
DR   TreeFam; TF343107; -.
DR   Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR   PRO; PR:Q5QD25; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="Trace amine-associated receptor 2"
FT                   /id="PRO_0000070148"
FT   TOPO_DOM        1..36
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..106
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..287
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..310
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        311..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        277
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        104..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   339 AA;  38557 MW;  9F70097B9B8CA9C9 CRC64;
     MTSFEAQQET FDCSEYGNGS CPENERSLGV RAAMYSLMAG AIFITIFGNL VMIISISYFK
     QLHTPTNLLI LSMAVTDFLL GFTIMPYSMV RSVENCWYFG LTFCKIHYSF DLMLSITSIF
     HLCSVAIDRF YAICHPLHYC TKMTIPVVKR LLLVCWSVPG AFAFGVVFSE AYADGIEGYD
     ILVACSSSCP VMFNKLWGTT LFVAGFFTPS SMMVGIYGKI FAVSKKHARV IDNLPENQNN
     QMRKDKKAAK TLGIVMGVFL LCWFPCFFTI LLDPFLNFST PAILFDALTW FGYFNSTCNP
     LIYGFFYPWF RRALRYILLG KIFSSHFHNT NLFTQKETE