TAAR3_HUMAN
ID TAAR3_HUMAN Reviewed; 343 AA.
AC Q9P1P4;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Putative trace amine-associated receptor 3;
DE Short=TaR-3;
DE Short=Trace amine receptor 3;
DE Short=hTaar3;
DE AltName: Full=G-protein coupled receptor 57;
GN Name=TAAR3P {ECO:0000312|HGNC:HGNC:4513}; Synonyms=GPR57, TAAR3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10684976; DOI=10.1016/s0167-4781(99)00241-9;
RA Lee D.K., Lynch K.R., Nguyen T., Im D.-S., Cheng R., Saldivia V.R., Liu Y.,
RA Liu I.S.C., Heng H.H.Q., Seeman P., George S.R., O'Dowd B.F., Marchese A.;
RT "Cloning and characterization of additional members of the G protein-
RT coupled receptor family.";
RL Biochim. Biophys. Acta 1490:311-323(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Not expressed in the pons, thalamus, globus
CC pallidus, caudate, putamen or cerebellum.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AF112461; AAF27279.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9P1P4; -.
DR SMR; Q9P1P4; -.
DR IntAct; Q9P1P4; 8.
DR GlyGen; Q9P1P4; 1 site.
DR BioMuta; HGNC:4513; -.
DR DMDM; 38257784; -.
DR PRIDE; Q9P1P4; -.
DR GeneCards; TAAR3P; -.
DR HGNC; HGNC:4513; TAAR3P.
DR neXtProt; NX_Q9P1P4; -.
DR InParanoid; Q9P1P4; -.
DR PhylomeDB; Q9P1P4; -.
DR PathwayCommons; Q9P1P4; -.
DR Reactome; R-HSA-375280; Amine ligand-binding receptors.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; Q9P1P4; -.
DR Pharos; Q9P1P4; Tdark.
DR PRO; PR:Q9P1P4; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9P1P4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0001594; F:trace-amine receptor activity; ISS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..343
FT /note="Putative trace amine-associated receptor 3"
FT /id="PRO_0000070149"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..168
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 343 AA; 39065 MW; DC513D15ABBC026F CRC64;
MDLTYIPEDL SSCPKFVNKI LSSHQPLFSC PGDNVFGYDW SHDYPLFGNL VIMVSISHFK
QLHSPTNFLI LSMATTDFLL GFVIMPYSIM RSVESCWYFG DGFCKFHTSF DMMLRLTSIF
HLCSIAIDRF YAVCYPLHYT TKMTNSTIKQ LLAFCWSVPA LFSFGLVLSE ADVSGMQSYK
ILVACFNFCA LTFNKFWGTI LFTTCFFTPG SIMVGIYGKI FIVSKQHARV ISHVPENTKG
AVKKHLSKKK DRKAAKTLGI VMGVFLACWL PCFLAVLIDP YLDYSTPILI LDLLVWLRYF
NSTCNPLIHG FFNPWFQKAF KYIVSGKIFS SHSETANLFP EAH
