TAAR3_MOUSE
ID TAAR3_MOUSE Reviewed; 343 AA.
AC Q5QD16; B2RT86;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Trace amine-associated receptor 3;
DE Short=TaR-3;
DE Short=Trace amine receptor 3;
DE Short=mTaar3;
GN Name=Taar3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Olfactory receptor activated by several primary trace amines,
CC including isoamylamine. Activated by isoamylamine and cyclohexylamine,
CC but not to the corresponding alcohols, isoamylalcohol and cyclohexanol.
CC This receptor is probably mediated by the G(s)-class of G-proteins
CC which activate adenylate cyclase. {ECO:0000269|PubMed:16878137}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium. {ECO:0000269|PubMed:16878137}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702327; AAV70137.1; -; Genomic_DNA.
DR EMBL; BC139171; AAI39172.1; -; mRNA.
DR EMBL; BC139172; AAI39173.1; -; mRNA.
DR CCDS; CCDS23736.1; -.
DR RefSeq; NP_001008429.1; NM_001008429.1.
DR AlphaFoldDB; Q5QD16; -.
DR SMR; Q5QD16; -.
DR STRING; 10090.ENSMUSP00000036817; -.
DR GuidetoPHARMACOLOGY; 168; -.
DR GlyGen; Q5QD16; 2 sites.
DR PaxDb; Q5QD16; -.
DR PRIDE; Q5QD16; -.
DR DNASU; 493809; -.
DR Ensembl; ENSMUST00000045152; ENSMUSP00000036817; ENSMUSG00000069708.
DR GeneID; 493809; -.
DR KEGG; mmu:493809; -.
DR UCSC; uc007eqf.1; mouse.
DR CTD; 493809; -.
DR MGI; MGI:3527427; Taar3.
DR VEuPathDB; HostDB:ENSMUSG00000069708; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163260; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD16; -.
DR OMA; CALAFNK; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD16; -.
DR TreeFam; TF343107; -.
DR Reactome; R-MMU-375280; Amine ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 493809; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q5QD16; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD16; protein.
DR ExpressionAtlas; Q5QD16; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IDA:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..343
FT /note="Trace amine-associated receptor 3"
FT /id="PRO_0000070150"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..168
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 343 AA; 38745 MW; 2A3F7D7BFC93AABF CRC64;
MDLIYIPEDL SSCPKFGNKS CPPTNRSFRV RMIMYLFMTG AMVITIFGNL VIIISISHFK
QLHSPTNFLI LSMATTDFLL GFVIMPYSMV RSVESCWYFG DSFCKFHASF DMMLSLTSIF
HLCSIAIDRF YAVCDPLHYT TTMTVSMIKR LLAFCWAAPA LFSFGLVLSE ANVSGMQSYE
ILVACFNFCA LTFNKFWGTI LFTTCFFTPG SIMVGIYGKI FIVSRRHARA LSDMPANTKG
AVGKNLSKKK DRKAAKTLGI VMGVFLACWL PCFLAVLIDP YLDYSTPIIV LDLLVWLGYF
NSTCNPLIHG FFYPWFRKAL QFIVSGKIFR SNSDTANLFP EAH
