TAAR3_RAT
ID TAAR3_RAT Reviewed; 342 AA.
AC Q5QD24;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Trace amine-associated receptor 3;
DE Short=TaR-3;
DE Short=Trace amine receptor 3;
GN Name=Taar3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=WIST/Crl;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Olfactory receptor activated by several primary trace amines,
CC including isoamylamine. Activated by isoamylamine and cyclohexylamine,
CC but not to the corresponding alcohols, isoamylalcohol and cyclohexanol.
CC This receptor is probably mediated by the G(s)-class of G-proteins
CC which activate adenylate cyclase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702317; AAV70129.1; -; Genomic_DNA.
DR RefSeq; NP_001009532.1; NM_001009532.1.
DR AlphaFoldDB; Q5QD24; -.
DR SMR; Q5QD24; -.
DR STRING; 10116.ENSRNOP00000035248; -.
DR GlyGen; Q5QD24; 2 sites.
DR PaxDb; Q5QD24; -.
DR Ensembl; ENSRNOT00000035539; ENSRNOP00000035248; ENSRNOG00000025982.
DR GeneID; 494319; -.
DR KEGG; rno:494319; -.
DR CTD; 493809; -.
DR RGD; 1359566; Taar3.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163260; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD24; -.
DR OMA; CALAFNK; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD24; -.
DR TreeFam; TF343107; -.
DR Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR PRO; PR:Q5QD24; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000025982; Expressed in testis.
DR ExpressionAtlas; Q5QD24; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; ISS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="Trace amine-associated receptor 3"
FT /id="PRO_0000070151"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..168
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 342 AA; 38658 MW; 2473C99F1793C1BE CRC64;
MDLIYIPEDL SSCPKFGNKS CPPTNRSFRV RLIMYLLMTG AMVITIFGNL VIIISISHFK
QLHSPTNFLI LSMATTDFLL GFVIMPYSMV RSVESCWYFG DSFCKFHASF DMMLSLTSIF
HLCSIAIDRF YAVCAPLHYT TTMTASMIKR LLFFCWAAPA LFSFGLVLSE ANVSGMQSYE
ILIACFNFCA LTFNKFWGTI LFTTCFFTPG SIMVGIYGKI FIVSRRHARA LGNMPENTKG
AGRNLSKKKD RKAAKTLGIV MGVFLACWLP CFLAVLIDPY LDYSTPIIVL DLLVWLGYFN
STCNPLIHGF FYPWFRKALE HIVSGKIFRS NSDTANLFPE AH
