TAAR4_MOUSE
ID TAAR4_MOUSE Reviewed; 347 AA.
AC Q5QD15;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Trace amine-associated receptor 4;
DE Short=TaR-4;
DE Short=Trace amine receptor 4;
DE Short=mTaar4;
DE AltName: Full=2-phenylethylamine receptor;
GN Name=Taar4; Synonyms=Gm226;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [3]
RP FUNCTION.
RX PubMed=21690383; DOI=10.1073/pnas.1103317108;
RA Ferrero D.M., Lemon J.K., Fluegge D., Pashkovski S.L., Korzan W.J.,
RA Datta S.R., Spehr M., Fendt M., Liberles S.D.;
RT "Detection and avoidance of a carnivore odor by prey.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:11235-11240(2011).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=22837392; DOI=10.1073/pnas.1206724109;
RA Johnson M.A., Tsai L., Roy D.S., Valenzuela D.H., Mosley C., Magklara A.,
RA Lomvardas S., Liberles S.D., Barnea G.;
RT "Neurons expressing trace amine-associated receptors project to discrete
RT glomeruli and constitute an olfactory subsystem.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:13410-13415(2012).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Olfactory receptor specific for 2-phenylethylamine, a trace
CC amine present at high concentration in the urine of carnivore species,
CC playing a key role in fear and avoidance responses. 2-phenylethylamine
CC acts as a kairomone in the chemical detection of carnivore odor and
CC triggers fear in mice. This receptor is probably mediated by the G(s)-
CC class of G-proteins which activate adenylate cyclase.
CC {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:21690383,
CC ECO:0000269|PubMed:23624375}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium, to discrete glomeruli predominantly localized to a confined
CC bulb region. Present in the dorsal area of the main olfactory
CC epithelium. {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:22837392}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar4 show an absence of aversion to
CC low concentrations of volatile amines and to the odor of predator
CC urine. {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702328; AAV70138.1; -; Genomic_DNA.
DR CCDS; CCDS23737.1; -.
DR RefSeq; NP_001008499.1; NM_001008499.1.
DR AlphaFoldDB; Q5QD15; -.
DR SMR; Q5QD15; -.
DR STRING; 10090.ENSMUSP00000090330; -.
DR GuidetoPHARMACOLOGY; 169; -.
DR GlyGen; Q5QD15; 1 site.
DR PaxDb; Q5QD15; -.
DR PRIDE; Q5QD15; -.
DR DNASU; 209513; -.
DR Ensembl; ENSMUST00000092660; ENSMUSP00000090330; ENSMUSG00000069707.
DR GeneID; 209513; -.
DR KEGG; mmu:209513; -.
DR UCSC; uc007eqg.1; mouse.
DR CTD; 209513; -.
DR MGI; MGI:2685072; Taar4.
DR VEuPathDB; HostDB:ENSMUSG00000069707; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162730; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD15; -.
DR OMA; LWNPPEV; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD15; -.
DR TreeFam; TF343107; -.
DR BioGRID-ORCS; 209513; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q5QD15; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD15; protein.
DR Bgee; ENSMUSG00000069707; Expressed in nose and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990080; F:2-phenylethylamine receptor activity; IDA:UniProtKB.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; ISO:MGI.
DR GO; GO:0001594; F:trace-amine receptor activity; ISO:MGI.
DR GO; GO:0001662; P:behavioral fear response; IMP:UniProtKB.
DR GO; GO:0007635; P:chemosensory behavior; IMP:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Behavior; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Trace amine-associated receptor 4"
FT /id="PRO_0000070152"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 347 AA; 38904 MW; B1564F458416C9C0 CRC64;
MNTPDPWSSP EVQFCFAAAN SSCPRKARPA LVVCAMYLIM IGAIVMTMLG NMAVIISIAH
FKQLHSPTNF LILSMATTDF LLSCVVMPFS MIRSIESCWY FGDLFCKVHS CCDIMLCTTS
IFHLCFISVD RHYAVCDPLH YVTQITTRVV GVFLLISWSV PIFFAFGLVF SELNLIGAED
FVAAIDCTGL CVLIFNKLWG VLASFIAFFL PGTVMVGIYI HIFTVAQKHA RQIGTGPRTK
QALSESKMKA TSKKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIDFTT PEDLYNVFLW
LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP
