TAAR4_RAT
ID TAAR4_RAT Reviewed; 347 AA.
AC Q923Y7;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Trace amine-associated receptor 4;
DE Short=TaR-4;
DE Short=Trace amine receptor 4;
DE AltName: Full=2-phenylethylamine receptor;
DE AltName: Full=Trace amine receptor 2;
DE Short=TaR-2;
GN Name=Taar4; Synonyms=Ta2, Tar2, Trar2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC -!- FUNCTION: Olfactory receptor specific for 2-phenylethylamine, a trace
CC amine present at high concentration in the urine of carnivore species,
CC playing a key role in fear and avoidance responses. 2-phenylethylamine
CC acts as a kairomone in the chemical detection of carnivore odor and
CC triggers fear in mice. This receptor is probably mediated by the G(s)-
CC class of G-proteins which activate adenylate cyclase (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380188; AAK71239.1; -; Genomic_DNA.
DR RefSeq; NP_783173.1; NM_175583.1.
DR AlphaFoldDB; Q923Y7; -.
DR SMR; Q923Y7; -.
DR STRING; 10116.ENSRNOP00000050289; -.
DR GlyGen; Q923Y7; 1 site.
DR PaxDb; Q923Y7; -.
DR PRIDE; Q923Y7; -.
DR Ensembl; ENSRNOT00000047810; ENSRNOP00000050289; ENSRNOG00000029877.
DR GeneID; 294122; -.
DR KEGG; rno:294122; -.
DR CTD; 209513; -.
DR RGD; 631382; Taar4.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162730; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q923Y7; -.
DR OMA; LWNPPEV; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q923Y7; -.
DR TreeFam; TF343107; -.
DR PRO; PR:Q923Y7; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000029877; Expressed in testis and 1 other tissue.
DR ExpressionAtlas; Q923Y7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990080; F:2-phenylethylamine receptor activity; IBA:GO_Central.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; IDA:MGI.
DR GO; GO:0001594; F:trace-amine receptor activity; IDA:RGD.
DR GO; GO:0001662; P:behavioral fear response; IBA:GO_Central.
DR GO; GO:0007635; P:chemosensory behavior; IBA:GO_Central.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Behavior; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Trace amine-associated receptor 4"
FT /id="PRO_0000070153"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 347 AA; 38783 MW; B6294B2876618DB9 CRC64;
MNSPDLWYSP ETQFCFAAAN NSCPRKARPA LVVCAMYLVM IGAIVMTMLG NMVVIISIAH
FKQLHSPTNF LILSMATTDF LLSCVVMPFS MVRSIESCWY FGDLFCKVHS CCDIMLCTTS
IFHLCFISVD RHYAVCDPLH YVTQITVGVV GVFLLISWSV PILFAFGLVF SELNLIGAED
FVAAIDCTGL CVLIFNKLWG VLASFIAFFL PGAIMVGIYI HIFTVARKHA RKIGPGPRTK
RALSESKMKA TSGKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIGFTT PEDLYNVFLW
LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP
