TAAR5_MOUSE
ID TAAR5_MOUSE Reviewed; 337 AA.
AC Q5QD14;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Trace amine-associated receptor 5;
DE Short=TaR-5;
DE Short=Trace amine receptor 5;
DE Short=mTaar5;
DE AltName: Full=Trimethylamine receptor;
GN Name=Taar5; Synonyms=Gm227;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22837392; DOI=10.1073/pnas.1206724109;
RA Johnson M.A., Tsai L., Roy D.S., Valenzuela D.H., Mosley C., Magklara A.,
RA Lomvardas S., Liberles S.D., Barnea G.;
RT "Neurons expressing trace amine-associated receptors project to discrete
RT glomeruli and constitute an olfactory subsystem.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:13410-13415(2012).
RN [4]
RP FUNCTION.
RX PubMed=23177478; DOI=10.1016/j.cub.2012.10.047;
RA Li Q., Korzan W.J., Ferrero D.M., Chang R.B., Roy D.S., Buchi M.,
RA Lemon J.K., Kaur A.W., Stowers L., Fendt M., Liberles S.D.;
RT "Synchronous evolution of an odor biosynthesis pathway and behavioral
RT response.";
RL Curr. Biol. 23:11-20(2013).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Olfactory receptor specific for trimethylamine, a trace amine
CC enriched in the urine of male mice, playing a role in social behavior.
CC Trimethylamine is present at high concentration in the urine of male
CC mice after puberty and acts as an attractant. This receptor is probably
CC mediated by the G(s)-class of G-proteins which activate adenylate
CC cyclase. {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:23177478}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium, to discrete glomeruli predominantly localized to a confined
CC bulb region. Present in the dorsal area of the main olfactory
CC epithelium. {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:22837392}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- MISCELLANEOUS: Trimethylamine is a bacterial metabolite found in some
CC animal odors, and is a repulsive odor associated with bad breath and
CC spoiled food for most organisms, except for M.musculus, where it acts
CC as an attractant (PubMed:16878137, PubMed:23177478).
CC {ECO:0000305|PubMed:16878137, ECO:0000305|PubMed:23177478}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702329; AAV70139.1; -; Genomic_DNA.
DR CCDS; CCDS23738.1; -.
DR RefSeq; NP_001009574.1; NM_001009574.1.
DR AlphaFoldDB; Q5QD14; -.
DR SMR; Q5QD14; -.
DR STRING; 10090.ENSMUSP00000090329; -.
DR BindingDB; Q5QD14; -.
DR ChEMBL; CHEMBL3784908; -.
DR GuidetoPHARMACOLOGY; 170; -.
DR GlyGen; Q5QD14; 1 site.
DR iPTMnet; Q5QD14; -.
DR PhosphoSitePlus; Q5QD14; -.
DR PaxDb; Q5QD14; -.
DR PRIDE; Q5QD14; -.
DR Antibodypedia; 19709; 228 antibodies from 29 providers.
DR DNASU; 215854; -.
DR Ensembl; ENSMUST00000092659; ENSMUSP00000090329; ENSMUSG00000069706.
DR GeneID; 215854; -.
DR KEGG; mmu:215854; -.
DR UCSC; uc007eqh.1; mouse.
DR CTD; 9038; -.
DR MGI; MGI:2685073; Taar5.
DR VEuPathDB; HostDB:ENSMUSG00000069706; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161258; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD14; -.
DR OMA; YQWFRKA; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD14; -.
DR TreeFam; TF343107; -.
DR Reactome; R-MMU-375280; Amine ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 215854; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q5QD14; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD14; protein.
DR Bgee; ENSMUSG00000069706; Expressed in membranous labyrinth and 6 other tissues.
DR ExpressionAtlas; Q5QD14; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR GO; GO:1990081; F:trimethylamine receptor activity; IDA:UniProtKB.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007617; P:mating behavior; TAS:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IDA:UniProtKB.
DR GO; GO:0035176; P:social behavior; TAS:UniProtKB.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Behavior; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..337
FT /note="Trace amine-associated receptor 5"
FT /id="PRO_0000070155"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 337 AA; 38220 MW; 25B14CDEE31CB915 CRC64;
MRAVLLPGSG EQPTAFCYQV NGSCPRTVHP LAIQVVIYLA CAVGVLITVL GNLFVVFAVS
YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW FFGDFLCRLH TYLDTLFCLT
SIFHLCFISI DRHCAICDPL LYPSKFTVRT ALRYIVAGWG IPAAYTAFFL YTDVVERALS
QWLEEMPCVG SCQLLFNKFW GWLNFPAFFV PCLIMISLYL KIFVVATRQA QQIRTLSQSL
AGAVKRERKA AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF ITPPLVFDIF IWFAYFNSAC
NPIIYVFSYR WFRKALKLLL SREIFSPRTP TVDLYHD
