TAAR5_PANTR
ID TAAR5_PANTR Reviewed; 337 AA.
AC Q5QD28;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Trace amine-associated receptor 5;
DE Short=TaR-5;
DE Short=Trace amine receptor 5;
GN Name=TAAR5;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Olfactory receptor specific for trimethylamine, a trace
CC amine. Also activated at lower level by dimethylethylamine.
CC Trimethylamine is a bacterial metabolite found in some animal odors,
CC and is a repulsive odor associated with bad breath and spoiled food.
CC This receptor is probably mediated by the G(s)-class of G-proteins
CC which activate adenylate cyclase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702311; AAV70125.1; -; Genomic_DNA.
DR RefSeq; NP_001009126.1; NM_001009126.1.
DR AlphaFoldDB; Q5QD28; -.
DR SMR; Q5QD28; -.
DR STRING; 9598.ENSPTRP00000031768; -.
DR PaxDb; Q5QD28; -.
DR Ensembl; ENSPTRT00000034368; ENSPTRP00000031768; ENSPTRG00000018611.
DR GeneID; 472128; -.
DR KEGG; ptr:472128; -.
DR CTD; 9038; -.
DR VGNC; VGNC:3719; TAAR5.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161258; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD28; -.
DR OMA; YQWFRKA; -.
DR OrthoDB; 913195at2759; -.
DR TreeFam; TF343107; -.
DR Proteomes; UP000002277; Chromosome 6.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR GO; GO:1990081; F:trimethylamine receptor activity; IEA:Ensembl.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="Trace amine-associated receptor 5"
FT /id="PRO_0000070156"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 337 AA; 38265 MW; 4285E5A8723E6BEB CRC64;
MRAVFIQGAE EHPAAFCYQV NGSCPRTVHT LGIQLVIYLA CAAGMLIIVL GNLFVAFAVS
YFKALHTPTN FLLLSLALAD MFLGLLVLPL STIRSVESCW FFGDFLCRLH TYLDPLFCLT
SIFHLCFISI DRHCAICDPL LYPSKFTVRV ALRYILAGWG VPAAYTSLFL YTDVVETRLS
QWLEEMPCVG SCQLLLNKFW GWLNFPLFFV PCLIMISLYV KIFVVATRQA QQITTLSKNL
AGAAKHDRKA AKTLGIAVGI YLLCWLPFTI DTMVDSLLHF ITPPLVFDIF IWFAYFNSAC
NPIIYVFSYQ WFRKALKLTL SQKVFSPQTR TVDLYQE
