TAAR5_RAT
ID TAAR5_RAT Reviewed; 337 AA.
AC Q5QD23;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Trace amine-associated receptor 5;
DE Short=TaR-5;
DE Short=Trace amine receptor 5;
GN Name=Taar5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=WIST/Crl;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Olfactory receptor specific for trimethylamine, a trace
CC amine. Also activated at lower level by dimethylethylamine.
CC Trimethylamine is a bacterial metabolite found in some animal odors,
CC and is a repulsive odor associated with bad breath and spoiled food.
CC This receptor is probably mediated by the G(s)-class of G-proteins
CC which activate adenylate cyclase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702318; AAV70130.1; -; Genomic_DNA.
DR RefSeq; NP_001009650.1; NM_001009650.1.
DR AlphaFoldDB; Q5QD23; -.
DR SMR; Q5QD23; -.
DR STRING; 10116.ENSRNOP00000057922; -.
DR GlyGen; Q5QD23; 1 site.
DR PhosphoSitePlus; Q5QD23; -.
DR PaxDb; Q5QD23; -.
DR Ensembl; ENSRNOT00000061209; ENSRNOP00000057922; ENSRNOG00000039869.
DR GeneID; 294123; -.
DR KEGG; rno:294123; -.
DR CTD; 9038; -.
DR RGD; 1359185; Taar5.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161258; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD23; -.
DR OMA; YQWFRKA; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD23; -.
DR TreeFam; TF343107; -.
DR Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR PRO; PR:Q5QD23; -.
DR Proteomes; UP000002494; Chromosome 1.
DR ExpressionAtlas; Q5QD23; differential.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR GO; GO:1990081; F:trimethylamine receptor activity; ISO:RGD.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; ISO:RGD.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="Trace amine-associated receptor 5"
FT /id="PRO_0000070157"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 337 AA; 38218 MW; DB013609BDAD6C67 CRC64;
MRAVLLPGSG EQPAAFCYQV NGSCPRTVHP LAIRVLIYLA CAVGMLITVL GNLFVVFAVS
YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW FFGDFLCRLH TYLDTLFCLT
SIFHLCFISI DRHCAICDPL LYPSKFTVRI ALRYIAAGWG IPAAYTAFFL YTDVVERALS
QWLEEMPCVG SCQLLFNKFW GWLNFPAFFI PCLIMISLYL KIFVVATRQA QQIRTLSQSL
SGAVKRERKA AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF VTPPLVFDIF IWFAYFNSAC
NPIIYVFSYR WFRKALKLLL SREILSPRTQ TADLFHD
