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TAAR6_HUMAN
ID   TAAR6_HUMAN             Reviewed;         345 AA.
AC   Q96RI8; Q5VUQ4;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Trace amine-associated receptor 6;
DE            Short=TaR-6;
DE            Short=Trace amine receptor 6;
DE   AltName: Full=Trace amine receptor 4;
DE            Short=TaR-4;
GN   Name=TAAR6; Synonyms=TA4, TAR4, TRAR4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11459929; DOI=10.1073/pnas.151105198;
RA   Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA   Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA   Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA   Gerald C.;
RT   "Trace amines: identification of a family of mammalian G protein-coupled
RT   receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   VARIANTS THR-37; SER-165; CYS-173; VAL-228; ILE-265; TYR-291 AND ILE-326,
RP   AND TISSUE SPECIFICITY.
RX   PubMed=15329799; DOI=10.1086/424887;
RA   Duan J., Martinez M., Sanders A.R., Hou C., Saitou N., Kitano T.,
RA   Mowry B.J., Crowe R.R., Silverman J.M., Levinson D.F., Gejman P.V.;
RT   "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome
RT   6q23.2 are associated with susceptibility to schizophrenia.";
RL   Am. J. Hum. Genet. 75:624-638(2004).
CC   -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC       amines are biogenic amines present in very low levels in mammalian
CC       tissues. Although some trace amines have clearly defined roles as
CC       neurotransmitters in invertebrates, the extent to which they function
CC       as true neurotransmitters in vertebrates has remained speculative.
CC       Trace amines are likely to be involved in a variety of physiological
CC       functions that have yet to be fully understood.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed at low abundance in various brain
CC       tissues, as well as in fetal liver, but not in the cerebellum or
CC       placenta. In the brain, comparable levels of expression in basal
CC       ganglia, frontal cortex, substantia nigra, amygdala and hippocampus,
CC       highest expression in hippocampus and lowest expression in basal
CC       ganglia. {ECO:0000269|PubMed:15329799}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF380192; AAK71243.1; -; Genomic_DNA.
DR   EMBL; AY183470; AAO24661.1; -; mRNA.
DR   EMBL; AL513524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069157; AAH69157.1; -; mRNA.
DR   CCDS; CCDS5155.1; -.
DR   RefSeq; NP_778237.1; NM_175067.1.
DR   AlphaFoldDB; Q96RI8; -.
DR   SMR; Q96RI8; -.
DR   STRING; 9606.ENSP00000275198; -.
DR   ChEMBL; CHEMBL4523910; -.
DR   GlyGen; Q96RI8; 2 sites.
DR   iPTMnet; Q96RI8; -.
DR   PhosphoSitePlus; Q96RI8; -.
DR   BioMuta; TAAR6; -.
DR   DMDM; 38258634; -.
DR   PaxDb; Q96RI8; -.
DR   PRIDE; Q96RI8; -.
DR   Antibodypedia; 19707; 95 antibodies from 22 providers.
DR   DNASU; 319100; -.
DR   Ensembl; ENST00000275198.1; ENSP00000275198.1; ENSG00000146383.7.
DR   GeneID; 319100; -.
DR   KEGG; hsa:319100; -.
DR   MANE-Select; ENST00000275198.1; ENSP00000275198.1; NM_175067.1; NP_778237.1.
DR   UCSC; uc011eck.2; human.
DR   CTD; 319100; -.
DR   DisGeNET; 319100; -.
DR   GeneCards; TAAR6; -.
DR   HGNC; HGNC:20978; TAAR6.
DR   HPA; ENSG00000146383; Not detected.
DR   MIM; 608923; gene.
DR   neXtProt; NX_Q96RI8; -.
DR   OpenTargets; ENSG00000146383; -.
DR   PharmGKB; PA134881141; -.
DR   VEuPathDB; HostDB:ENSG00000146383; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000160008; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q96RI8; -.
DR   OMA; EICVWCA; -.
DR   OrthoDB; 816088at2759; -.
DR   PhylomeDB; Q96RI8; -.
DR   TreeFam; TF343107; -.
DR   PathwayCommons; Q96RI8; -.
DR   Reactome; R-HSA-375280; Amine ligand-binding receptors.
DR   Reactome; R-HSA-418555; G alpha (s) signalling events.
DR   Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR   BioGRID-ORCS; 319100; 15 hits in 1061 CRISPR screens.
DR   GeneWiki; TAAR6; -.
DR   GenomeRNAi; 319100; -.
DR   Pharos; Q96RI8; Tbio.
DR   PRO; PR:Q96RI8; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q96RI8; protein.
DR   Bgee; ENSG00000146383; Expressed in ganglionic eminence and 7 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..345
FT                   /note="Trace amine-associated receptor 6"
FT                   /id="PRO_0000070158"
FT   TOPO_DOM        1..32
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..259
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..276
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        277..282
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..302
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..345
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        105..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         37
FT                   /note="I -> T (in dbSNP:rs17061399)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019794"
FT   VARIANT         99
FT                   /note="Y -> C (in dbSNP:rs41298395)"
FT                   /id="VAR_061227"
FT   VARIANT         165
FT                   /note="G -> S (in dbSNP:rs17061401)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019795"
FT   VARIANT         173
FT                   /note="Y -> C (in dbSNP:rs17061404)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019796"
FT   VARIANT         228
FT                   /note="A -> V (in dbSNP:rs17061409)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019797"
FT   VARIANT         265
FT                   /note="V -> I (in dbSNP:rs8192624)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019798"
FT   VARIANT         291
FT                   /note="C -> Y (in dbSNP:rs8192625)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019799"
FT   VARIANT         326
FT                   /note="V -> I (in dbSNP:rs17061419)"
FT                   /evidence="ECO:0000269|PubMed:15329799"
FT                   /id="VAR_019800"
SQ   SEQUENCE   345 AA;  38451 MW;  21B1C4968C39FE2C CRC64;
     MSSNSSLLVA VQLCYANVNG SCVKIPFSPG SRVILYIVFG FGAVLAVFGN LLVMISILHF
     KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF GRSFCTFHTC CDVAFCYSSL
     FHLCFISIDR YIAVTDPLVY PTKFTVSVSG ICISVSWILP LMYSGAVFYT GVYDDGLEEL
     SDALNCIGGC QTVVNQNWVL TDFLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES
     SSESYKARVA RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA CIYEICCWCA
     YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI
 
 
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