TAAR6_HUMAN
ID TAAR6_HUMAN Reviewed; 345 AA.
AC Q96RI8; Q5VUQ4;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Trace amine-associated receptor 6;
DE Short=TaR-6;
DE Short=Trace amine receptor 6;
DE AltName: Full=Trace amine receptor 4;
DE Short=TaR-4;
GN Name=TAAR6; Synonyms=TA4, TAR4, TRAR4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANTS THR-37; SER-165; CYS-173; VAL-228; ILE-265; TYR-291 AND ILE-326,
RP AND TISSUE SPECIFICITY.
RX PubMed=15329799; DOI=10.1086/424887;
RA Duan J., Martinez M., Sanders A.R., Hou C., Saitou N., Kitano T.,
RA Mowry B.J., Crowe R.R., Silverman J.M., Levinson D.F., Gejman P.V.;
RT "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome
RT 6q23.2 are associated with susceptibility to schizophrenia.";
RL Am. J. Hum. Genet. 75:624-638(2004).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed at low abundance in various brain
CC tissues, as well as in fetal liver, but not in the cerebellum or
CC placenta. In the brain, comparable levels of expression in basal
CC ganglia, frontal cortex, substantia nigra, amygdala and hippocampus,
CC highest expression in hippocampus and lowest expression in basal
CC ganglia. {ECO:0000269|PubMed:15329799}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380192; AAK71243.1; -; Genomic_DNA.
DR EMBL; AY183470; AAO24661.1; -; mRNA.
DR EMBL; AL513524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069157; AAH69157.1; -; mRNA.
DR CCDS; CCDS5155.1; -.
DR RefSeq; NP_778237.1; NM_175067.1.
DR AlphaFoldDB; Q96RI8; -.
DR SMR; Q96RI8; -.
DR STRING; 9606.ENSP00000275198; -.
DR ChEMBL; CHEMBL4523910; -.
DR GlyGen; Q96RI8; 2 sites.
DR iPTMnet; Q96RI8; -.
DR PhosphoSitePlus; Q96RI8; -.
DR BioMuta; TAAR6; -.
DR DMDM; 38258634; -.
DR PaxDb; Q96RI8; -.
DR PRIDE; Q96RI8; -.
DR Antibodypedia; 19707; 95 antibodies from 22 providers.
DR DNASU; 319100; -.
DR Ensembl; ENST00000275198.1; ENSP00000275198.1; ENSG00000146383.7.
DR GeneID; 319100; -.
DR KEGG; hsa:319100; -.
DR MANE-Select; ENST00000275198.1; ENSP00000275198.1; NM_175067.1; NP_778237.1.
DR UCSC; uc011eck.2; human.
DR CTD; 319100; -.
DR DisGeNET; 319100; -.
DR GeneCards; TAAR6; -.
DR HGNC; HGNC:20978; TAAR6.
DR HPA; ENSG00000146383; Not detected.
DR MIM; 608923; gene.
DR neXtProt; NX_Q96RI8; -.
DR OpenTargets; ENSG00000146383; -.
DR PharmGKB; PA134881141; -.
DR VEuPathDB; HostDB:ENSG00000146383; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160008; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q96RI8; -.
DR OMA; EICVWCA; -.
DR OrthoDB; 816088at2759; -.
DR PhylomeDB; Q96RI8; -.
DR TreeFam; TF343107; -.
DR PathwayCommons; Q96RI8; -.
DR Reactome; R-HSA-375280; Amine ligand-binding receptors.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR BioGRID-ORCS; 319100; 15 hits in 1061 CRISPR screens.
DR GeneWiki; TAAR6; -.
DR GenomeRNAi; 319100; -.
DR Pharos; Q96RI8; Tbio.
DR PRO; PR:Q96RI8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96RI8; protein.
DR Bgee; ENSG00000146383; Expressed in ganglionic eminence and 7 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="Trace amine-associated receptor 6"
FT /id="PRO_0000070158"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 37
FT /note="I -> T (in dbSNP:rs17061399)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019794"
FT VARIANT 99
FT /note="Y -> C (in dbSNP:rs41298395)"
FT /id="VAR_061227"
FT VARIANT 165
FT /note="G -> S (in dbSNP:rs17061401)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019795"
FT VARIANT 173
FT /note="Y -> C (in dbSNP:rs17061404)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019796"
FT VARIANT 228
FT /note="A -> V (in dbSNP:rs17061409)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019797"
FT VARIANT 265
FT /note="V -> I (in dbSNP:rs8192624)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019798"
FT VARIANT 291
FT /note="C -> Y (in dbSNP:rs8192625)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019799"
FT VARIANT 326
FT /note="V -> I (in dbSNP:rs17061419)"
FT /evidence="ECO:0000269|PubMed:15329799"
FT /id="VAR_019800"
SQ SEQUENCE 345 AA; 38451 MW; 21B1C4968C39FE2C CRC64;
MSSNSSLLVA VQLCYANVNG SCVKIPFSPG SRVILYIVFG FGAVLAVFGN LLVMISILHF
KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF GRSFCTFHTC CDVAFCYSSL
FHLCFISIDR YIAVTDPLVY PTKFTVSVSG ICISVSWILP LMYSGAVFYT GVYDDGLEEL
SDALNCIGGC QTVVNQNWVL TDFLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES
SSESYKARVA RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA CIYEICCWCA
YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI