TAAR6_MOUSE
ID TAAR6_MOUSE Reviewed; 345 AA.
AC Q5QD13;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Trace amine-associated receptor 6;
DE Short=TaR-6;
DE Short=Trace amine receptor 6;
DE Short=mTaar6;
GN Name=Taar6; Synonyms=Gm228;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22837392; DOI=10.1073/pnas.1206724109;
RA Johnson M.A., Tsai L., Roy D.S., Valenzuela D.H., Mosley C., Magklara A.,
RA Lomvardas S., Liberles S.D., Barnea G.;
RT "Neurons expressing trace amine-associated receptors project to discrete
RT glomeruli and constitute an olfactory subsystem.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:13410-13415(2012).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Orphan olfactory receptor specific for trace amines.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium, to discrete glomeruli predominantly localized to a confined
CC bulb region. Present in a ventral area of the main olfactory
CC epithelium. {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:22837392}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702330; AAV70140.1; -; Genomic_DNA.
DR CCDS; CCDS23739.1; -.
DR RefSeq; NP_001010828.1; NM_001010828.1.
DR AlphaFoldDB; Q5QD13; -.
DR SMR; Q5QD13; -.
DR STRING; 10090.ENSMUSP00000097603; -.
DR GlyGen; Q5QD13; 1 site.
DR PhosphoSitePlus; Q5QD13; -.
DR PaxDb; Q5QD13; -.
DR PRIDE; Q5QD13; -.
DR DNASU; 215855; -.
DR Ensembl; ENSMUST00000057080; ENSMUSP00000097603; ENSMUSG00000045111.
DR GeneID; 215855; -.
DR KEGG; mmu:215855; -.
DR UCSC; uc007eqi.1; mouse.
DR CTD; 319100; -.
DR MGI; MGI:2685074; Taar6.
DR VEuPathDB; HostDB:ENSMUSG00000045111; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161306; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD13; -.
DR OMA; EICVWCA; -.
DR OrthoDB; 816088at2759; -.
DR PhylomeDB; Q5QD13; -.
DR TreeFam; TF343107; -.
DR Reactome; R-MMU-375280; Amine ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 215855; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q5QD13; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD13; protein.
DR Bgee; ENSMUSG00000045111; Expressed in septal olfactory organ and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="Trace amine-associated receptor 6"
FT /id="PRO_0000070159"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 345 AA; 38279 MW; EFF2226F4B92F9C9 CRC64;
MGSNSSPPTV LQLCYENVTG SCVKTPYSPG SRVILYAVFG FGAVLAVFGN LMVMISILHF
KQLHSPTNFL IASLACADFG VGISVMPFSM VRSIESCWYF GRSFCTFHTC CDVAFCYSSL
FHLSFISIDR YIAVTDPLVY PTKFTVSVSG ICIGVSWILP LVYSGAVFYT GVYDDGLEEL
SSALNCVGGC QVVVNQNWVL IDFLSFLIPT LVMIILYGNI FLVARQQAKK IENIGSKTES
SSESYKARVA RRERKAAKTL GITVVAFMIS WLPYSIDSLV DAFMGFITPA YIYEICVWCA
YYNSAMNPLI YALFYPWFKK AIKVIMSGQV FKNSSATMNL FSEQI
