TAAR6_PANTR
ID TAAR6_PANTR Reviewed; 345 AA.
AC Q5W8W0;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Trace amine-associated receptor 6;
DE Short=TaR-6;
DE Short=Trace amine receptor 6;
DE AltName: Full=Trace amine receptor 4;
DE Short=TaR-4;
GN Name=TAAR6; Synonyms=TRAR4;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate S109, and Isolate S286;
RX PubMed=15329799; DOI=10.1086/424887;
RA Duan J., Martinez M., Sanders A.R., Hou C., Saitou N., Kitano T.,
RA Mowry B.J., Crowe R.R., Silverman J.M., Levinson D.F., Gejman P.V.;
RT "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome
RT 6q23.2 are associated with susceptibility to schizophrenia.";
RL Am. J. Hum. Genet. 75:624-638(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB180398; BAD67188.1; -; Genomic_DNA.
DR EMBL; AB180397; BAD67187.1; -; Genomic_DNA.
DR EMBL; AY702312; AAV70126.1; -; Genomic_DNA.
DR RefSeq; NP_001009125.1; NM_001009125.1.
DR AlphaFoldDB; Q5W8W0; -.
DR SMR; Q5W8W0; -.
DR Ensembl; ENSPTRT00000034366; ENSPTRP00000088090; ENSPTRG00000018609.
DR GeneID; 472127; -.
DR KEGG; ptr:472127; -.
DR CTD; 319100; -.
DR GeneTree; ENSGT00940000160008; -.
DR InParanoid; Q5W8W0; -.
DR OMA; EICVWCA; -.
DR OrthoDB; 816088at2759; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018609; Expressed in skeletal muscle tissue and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="Trace amine-associated receptor 6"
FT /id="PRO_0000070160"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 345 AA; 38526 MW; 30A92377FC0EF245 CRC64;
MSSNSSLLVA VQLCYPNVNG SCVETLYSPG SRVILYIVFG FGAVLAVFGN LLVMISILHF
KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF GRSFCTFHTC CDVAFCYSSL
FHLCFISIDR YIAVTDPLVY PTKFTVSVSG ICISVSWILP LMYSGAVFYT GVYDDGLEEL
SDALNCIGGC QTVVNQNWVL IDCLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES
SSESYKARVA RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA YIYEICCWCA
YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI
