TAAR6_RAT
ID TAAR6_RAT Reviewed; 345 AA.
AC Q923Y5;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Trace amine-associated receptor 6;
DE Short=TaR-6;
DE Short=Trace amine receptor 6;
DE AltName: Full=Trace amine receptor 4;
DE Short=TaR-4;
GN Name=Taar6; Synonyms=Ta4, Tar4, Trar4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380191; AAK71242.1; -; Genomic_DNA.
DR RefSeq; NP_783174.1; NM_175584.1.
DR AlphaFoldDB; Q923Y5; -.
DR SMR; Q923Y5; -.
DR GlyGen; Q923Y5; 1 site.
DR PhosphoSitePlus; Q923Y5; -.
DR Ensembl; ENSRNOT00000021529; ENSRNOP00000070620; ENSRNOG00000016089.
DR GeneID; 294124; -.
DR KEGG; rno:294124; -.
DR CTD; 319100; -.
DR RGD; 631384; Taar6.
DR GeneTree; ENSGT00940000161306; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q923Y5; -.
DR OMA; EICVWCA; -.
DR OrthoDB; 816088at2759; -.
DR PhylomeDB; Q923Y5; -.
DR Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR PRO; PR:Q923Y5; -.
DR Proteomes; UP000002494; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="Trace amine-associated receptor 6"
FT /id="PRO_0000070161"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 345 AA; 38311 MW; DC904127D5B406EC CRC64;
MGSNSSPPAV LQLCYENVNG SCVKTPYSPG PRVLLYAVFG FGAVLAVFGN LLVMISILHF
KQLHSPTNFL IASLACADFW VGVSVMPFSM VRSIESCWYF GRSFCTFHTC CDVAFCYSSL
FHLSFISIDR YIAVTDPLVY PTKFTVSVSG ICISISWILP LAYSGAVFYT GVYADGLEEV
SDAVNCVGGC QVVVNQNWVL IDFLSFLIPT LVMIILYGNI FLVARQQAKK IETVGNKAES
SSESYKARVA RRERKAAKTL GITVVAFMIS WLPYSIDSLV DAFMGFITPA YIYEICVWCA
YYNSAMNPLI YALFYPWFKK AIKVIMSGQV FKNSSATMNL FSEQI
