TAAR9_HUMAN
ID TAAR9_HUMAN Reviewed; 348 AA.
AC Q96RI9;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Trace amine-associated receptor 9;
DE Short=TaR-9;
DE Short=Trace amine receptor 9;
DE AltName: Full=Trace amine receptor 3;
DE Short=TaR-3;
GN Name=TAAR9; Synonyms=TA3, TAR3, TRAR3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- INTERACTION:
CC Q96RI9; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-12908048, EBI-12266234;
CC Q96RI9; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12908048, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380189; AAK71240.1; -; Genomic_DNA.
DR EMBL; AY183469; AAO24660.1; -; mRNA.
DR CCDS; CCDS75520.1; -.
DR RefSeq; NP_778227.3; NM_175057.3.
DR AlphaFoldDB; Q96RI9; -.
DR SMR; Q96RI9; -.
DR BioGRID; 126415; 2.
DR IntAct; Q96RI9; 2.
DR STRING; 9606.ENSP00000424607; -.
DR ChEMBL; CHEMBL4523911; -.
DR GlyGen; Q96RI9; 2 sites.
DR iPTMnet; Q96RI9; -.
DR PhosphoSitePlus; Q96RI9; -.
DR BioMuta; TAAR9; -.
DR DMDM; 38258635; -.
DR PRIDE; Q96RI9; -.
DR Antibodypedia; 72575; 126 antibodies from 22 providers.
DR DNASU; 134860; -.
DR Ensembl; ENST00000434551.2; ENSP00000424607.2; ENSG00000237110.2.
DR GeneID; 134860; -.
DR KEGG; hsa:134860; -.
DR MANE-Select; ENST00000434551.3; ENSP00000424607.2; NM_175057.4; NP_778227.3.
DR UCSC; uc032xme.2; human.
DR CTD; 134860; -.
DR GeneCards; TAAR9; -.
DR HGNC; HGNC:20977; TAAR9.
DR HPA; ENSG00000237110; Not detected.
DR MIM; 608282; gene.
DR neXtProt; NX_Q96RI9; -.
DR OpenTargets; ENSG00000237110; -.
DR PharmGKB; PA134931528; -.
DR VEuPathDB; HostDB:ENSG00000237110; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162919; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q96RI9; -.
DR OMA; MVFIYSK; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q96RI9; -.
DR PathwayCommons; Q96RI9; -.
DR Reactome; R-HSA-375280; Amine ligand-binding receptors.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; Q96RI9; -.
DR BioGRID-ORCS; 134860; 8 hits in 238 CRISPR screens.
DR GeneWiki; TAAR9; -.
DR GenomeRNAi; 134860; -.
DR Pharos; Q96RI9; Tbio.
DR PRO; PR:Q96RI9; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96RI9; protein.
DR Bgee; ENSG00000237110; Expressed in cortical plate.
DR Genevisible; Q96RI9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..348
FT /note="Trace amine-associated receptor 9"
FT /id="PRO_0000070181"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..294
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 278
FT /note="A -> T (in dbSNP:rs9389004)"
FT /id="VAR_049449"
SQ SEQUENCE 348 AA; 39016 MW; D0C6484880A6F761 CRC64;
MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF
KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL
FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL
VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS
SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV
YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD
