TAAR9_MOUSE
ID TAAR9_MOUSE Reviewed; 348 AA.
AC Q5QD04; B2RT07;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Trace amine-associated receptor 9;
DE Short=TaR-9;
DE Short=Trace amine receptor 9;
DE Short=mTaar9;
GN Name=Taar9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Orphan olfactory receptor specific for trace amines.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium. {ECO:0000269|PubMed:16878137}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702340; AAV70149.1; -; Genomic_DNA.
DR EMBL; BC139084; AAI39085.1; -; mRNA.
DR EMBL; BC139085; AAI39086.1; -; mRNA.
DR CCDS; CCDS23748.1; -.
DR RefSeq; NP_001010831.1; NM_001010831.1.
DR AlphaFoldDB; Q5QD04; -.
DR SMR; Q5QD04; -.
DR STRING; 10090.ENSMUSP00000043552; -.
DR GlyGen; Q5QD04; 1 site.
DR PhosphoSitePlus; Q5QD04; -.
DR PaxDb; Q5QD04; -.
DR PRIDE; Q5QD04; -.
DR Antibodypedia; 72575; 126 antibodies from 22 providers.
DR Ensembl; ENSMUST00000041180; ENSMUSP00000043552; ENSMUSG00000037424.
DR GeneID; 503558; -.
DR KEGG; mmu:503558; -.
DR UCSC; uc007eqr.1; mouse.
DR CTD; 134860; -.
DR MGI; MGI:3527454; Taar9.
DR VEuPathDB; HostDB:ENSMUSG00000037424; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162919; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD04; -.
DR OMA; MVFIYSK; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QD04; -.
DR TreeFam; TF343107; -.
DR Reactome; R-MMU-375280; Amine ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 503558; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q5QD04; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD04; protein.
DR Bgee; ENSMUSG00000037424; Expressed in primary oocyte and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..348
FT /note="Trace amine-associated receptor 9"
FT /id="PRO_0000070182"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..294
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 348 AA; 38901 MW; 0164AAF9C5474BA8 CRC64;
MTSDFSPEPP MELCYENVNG SCIKSSYAPW PRAILYGVLG LGALLAVFGN LLVIIAILHF
KQLHTPTNFL VASLACADFL VGVTVMPFST VRSVESCWYF GESYCKFHTC FDTSFCFASL
FHLCCISIDR YIAVTDPLTY PTKFTVSVSG LCIALSWFFS VTYSFSIFYT GANEEGIEEL
VVALTCVGGC QAPLNQNWVL LCFLLFFLPT VVMVFLYGRI FLVAKYQARK IEGTANQAQA
SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYIIDAVI DAYMNFITPA YVYEILVWCV
YYNSAMNPLI YAFFYPWFRK AIKLIVSGKV FRADSSTTNL FSEEAGAG
