TAB2_DANRE
ID TAB2_DANRE Reviewed; 711 AA.
AC Q5RFW2; Q6NZS9;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;
DE AltName: Full=Mitogen-activated protein kinase kinase kinase 7-interacting protein 2;
DE AltName: Full=TGF-beta-activated kinase 1-binding protein 2;
GN Name=tab2; Synonyms=map3k7ip2; ORFNames=zgc:77446;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION IN HEART DEVELOPMENT.
RX PubMed=20493459; DOI=10.1016/j.ajhg.2010.04.011;
RA Thienpont B., Zhang L., Postma A.V., Breckpot J., Tranchevent L.C.,
RA Van Loo P., Mollgard K., Tommerup N., Bache I., Tumer Z., van Engelen K.,
RA Menten B., Mortier G., Waggoner D., Gewillig M., Moreau Y., Devriendt K.,
RA Larsen L.A.;
RT "Haploinsufficiency of TAB2 causes congenital heart defects in humans.";
RL Am. J. Hum. Genet. 86:839-849(2010).
CC -!- FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling
CC pathways through the specific recognition of 'Lys-63'-linked
CC polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an
CC adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin
CC chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-
CC 63'-linked polyubiquitin chains unanchored or anchored to the substrate
CC proteins such as RIPK1/RIP1: this acts as a scaffold to organize a
CC large signaling complex to promote autophosphorylation of MAP3K7/TAK1,
CC and subsequent activation of I-kappa-B-kinase (IKK) core complex by
CC MAP3K7/TAK1 (By similarity). Involved in heart development
CC (PubMed:20493459). {ECO:0000250|UniProtKB:Q9NYJ8,
CC ECO:0000269|PubMed:20493459}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NYJ8};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Cytoplasm,
CC cytosol {ECO:0000250|UniProtKB:Q9NYJ8}. Note=Following IL1 stimulation,
CC translocation occurs from the membrane to cytosol.
CC {ECO:0000250|UniProtKB:Q9NYJ8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5RFW2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RFW2-2; Sequence=VSP_019573, VSP_019574;
CC -!- DOMAIN: The RanBP2-type zinc finger (NZF) mediates binding to two
CC consecutive 'Lys-63'-linked ubiquitins. {ECO:0000250|UniProtKB:Q9NYJ8}.
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DR EMBL; CR536610; CAI11747.1; -; Genomic_DNA.
DR EMBL; CR536610; CAI11748.1; -; Genomic_DNA.
DR EMBL; BC065982; AAH65982.1; -; mRNA.
DR RefSeq; NP_001303622.1; NM_001316693.1. [Q5RFW2-1]
DR AlphaFoldDB; Q5RFW2; -.
DR STRING; 7955.ENSDARP00000019647; -.
DR PaxDb; Q5RFW2; -.
DR PRIDE; Q5RFW2; -.
DR DNASU; 494163; -.
DR Ensembl; ENSDART00000017791; ENSDARP00000019647; ENSDARG00000021509. [Q5RFW2-1]
DR GeneID; 494163; -.
DR KEGG; dre:494163; -.
DR CTD; 23118; -.
DR ZFIN; ZDB-GENE-040426-933; tab2.
DR eggNOG; ENOG502QRAY; Eukaryota.
DR GeneTree; ENSGT00940000158473; -.
DR HOGENOM; CLU_025065_0_0_1; -.
DR InParanoid; Q5RFW2; -.
DR OMA; GPTFIHH; -.
DR OrthoDB; 324984at2759; -.
DR PhylomeDB; Q5RFW2; -.
DR TreeFam; TF332021; -.
DR Reactome; R-DRE-168638; NOD1/2 Signaling Pathway.
DR Reactome; R-DRE-202424; Downstream TCR signaling.
DR Reactome; R-DRE-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-DRE-450302; activated TAK1 mediates p38 MAPK activation.
DR Reactome; R-DRE-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
DR Reactome; R-DRE-9020702; Interleukin-1 signaling.
DR Reactome; R-DRE-937042; IRAK2 mediated activation of TAK1 complex.
DR Reactome; R-DRE-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
DR PRO; PR:Q5RFW2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000021509; Expressed in muscle tissue and 33 other tissues.
DR ExpressionAtlas; Q5RFW2; baseline.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; ISS:UniProtKB.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IMP:ZFIN.
DR GO; GO:0007507; P:heart development; IMP:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; IBA:GO_Central.
DR CDD; cd14362; CUE_TAB2_TAB3; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR041911; TAB2/3_CUE.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR Pfam; PF02845; CUE; 1.
DR SMART; SM00546; CUE; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; SSF90209; 1.
DR PROSITE; PS51140; CUE; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Membrane; Metal-binding;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..711
FT /note="TGF-beta-activated kinase 1 and MAP3K7-binding
FT protein 2"
FT /id="PRO_0000225698"
FT DOMAIN 8..51
FT /note="CUE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT ZN_FING 681..711
FT /note="RanBP2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00322"
FT REGION 118..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 550..630
FT /evidence="ECO:0000255"
FT COMPBIAS 118..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 261..285
FT /note="QAPSIPSAVASQAVSSSPLPSSGSS -> HTHTRFTCVCARVRMPVCLIHGN
FT GR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_019573"
FT VAR_SEQ 286..711
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_019574"
SQ SEQUENCE 711 AA; 76880 MW; E26723DF30859356 CRC64;
MAQGNQQIDN QVLHHLRQKF PEVPEDVVCE CVLQNKSDLA ACCEYLTKVS PRFLYSEGSQ
SLTDLRNHMT QLNLGVSQNT HGAVQRDAVG MNGSRTLAPS VSDGPLNVPS ALSEFYQPET
PSVPTHTPAS LSMESTRKPQ PPQHLGLYQV GGKGHAPPQA PRFNPITVTL APNTGRNTPT
SLHIHGGPQS GLNSPNSIYI RPYVTQPGST RQVQCRAQYS PTSQPAQQIY QITHPAAPQS
SWSQHQTSHV YMPISSPTNT QAPSIPSAVA SQAVSSSPLP SSGSSFSQYN IQNISTGPRK
NQIEIKLESP QRGSGSSSLL RSSSAPRSAC SSTSSSCPSS CTSLASSSGS STPISIGGAG
LSRSQPTVYI SPSPPTAATA PSEDCALVPN TPRSQPKIYF SANTSADDGG GRNPPTVYIS
ANPALQGPAG LRALGSQMSM GPAYIHHHPP KSRPSVGAGG TATSPRVVVT QPNTKYTFKI
TVSPNKPPSV SPGVVSPTFE PNNMLSLPAD HHYAEPEISQ PDPMRDKAVE PRRLSMGADD
AAYTQALLVH QRARMERLWH ELELKKRKLE KLKEEVNEME SDLTRRRLQR SNAFCQIPSI
EEMQQLRCKN RLLQIDIDCL TKEIDLLQTR GPDFNPIAIH NFYDNLGFLG PVPPKPLKGP
TKAEVSRTDA GVRVLSEPEE DDGVQWSCTA CTFLNHPALN RCEECEFPRN F
