TABA_ECOLI
ID TABA_ECOLI Reviewed; 150 AA.
AC P0AF96; P39335; Q2M657;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Toxin-antitoxin biofilm protein TabA;
GN Name=tabA; Synonyms=yjgK; OrderedLocusNames=b4252, JW5756;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=B / BL21;
RX PubMed=10493123;
RX DOI=10.1002/(sici)1522-2683(19990801)20:11<2181::aid-elps2181>3.0.co;2-q;
RA Fountoulakis M., Takacs M.-F., Berndt P., Langen H., Takacs B.;
RT "Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite
RT chromatography.";
RL Electrophoresis 20:2181-2195(1999).
RN [5]
RP FUNCTION, INDUCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=19060153; DOI=10.1128/jb.01465-08;
RA Kim Y., Wang X., Ma Q., Zhang X.S., Wood T.K.;
RT "Toxin-antitoxin systems in Escherichia coli influence biofilm formation
RT through YjgK (TabA) and fimbriae.";
RL J. Bacteriol. 191:1258-1267(2009).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=K12 / JW1106, and K12 / MG1655 / ATCC 47076;
RX PubMed=18723842; DOI=10.1074/mcp.m800187-mcp200;
RA Zhang J., Sprung R., Pei J., Tan X., Kim S., Zhu H., Liu C.F.,
RA Grishin N.V., Zhao Y.;
RT "Lysine acetylation is a highly abundant and evolutionarily conserved
RT modification in Escherichia coli.";
RL Mol. Cell. Proteomics 8:215-225(2009).
CC -!- FUNCTION: Influences biofilm formation. Represses fimbria genes in 8
CC hours biofilms. May act in response to the combined activity of several
CC toxin-antitoxin (TA) systems. {ECO:0000269|PubMed:19060153}.
CC -!- INDUCTION: Induced by simultaneous deletion of five TA systems
CC (MazF/MazE, RelE/RelB, ChpB, YoeB/YefM, and YafQ/DinJ).
CC {ECO:0000269|PubMed:19060153}.
CC -!- DISRUPTION PHENOTYPE: Deletion increases biofilm formation after 8
CC hours and decreases biofilm formation after 24 hours.
CC {ECO:0000269|PubMed:19060153}.
CC -!- SIMILARITY: Belongs to the TabA/YiaL family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97148.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97148.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77209.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78249.1; -; Genomic_DNA.
DR PIR; S56477; S56477.
DR RefSeq; NP_418673.4; NC_000913.3.
DR RefSeq; WP_000583469.1; NZ_LN832404.1.
DR AlphaFoldDB; P0AF96; -.
DR SMR; P0AF96; -.
DR BioGRID; 4259562; 211.
DR DIP; DIP-48214N; -.
DR STRING; 511145.b4252; -.
DR iPTMnet; P0AF96; -.
DR jPOST; P0AF96; -.
DR PaxDb; P0AF96; -.
DR PRIDE; P0AF96; -.
DR EnsemblBacteria; AAC77209; AAC77209; b4252.
DR EnsemblBacteria; BAE78249; BAE78249; BAE78249.
DR GeneID; 58390508; -.
DR GeneID; 948777; -.
DR KEGG; ecj:JW5756; -.
DR KEGG; eco:b4252; -.
DR PATRIC; fig|1411691.4.peg.2452; -.
DR EchoBASE; EB2420; -.
DR eggNOG; COG2731; Bacteria.
DR HOGENOM; CLU_107139_3_0_6; -.
DR InParanoid; P0AF96; -.
DR OMA; CLIKVLM; -.
DR PhylomeDB; P0AF96; -.
DR BioCyc; EcoCyc:G7883-MON; -.
DR PRO; PR:P0AF96; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0044010; P:single-species biofilm formation; IMP:EcoCyc.
DR Gene3D; 2.60.120.370; -; 1.
DR InterPro; IPR004375; NanQ/TabA/YiaL.
DR InterPro; IPR037012; NanQ/TabA/YiaL_sf.
DR PANTHER; PTHR34986; PTHR34986; 1.
DR Pfam; PF04074; DUF386; 1.
DR TIGRFAMs; TIGR00022; TIGR00022; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT CHAIN 1..150
FT /note="Toxin-antitoxin biofilm protein TabA"
FT /id="PRO_0000169765"
FT MOD_RES 36
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000269|PubMed:18723842"
SQ SEQUENCE 150 AA; 16865 MW; 30E316B24C523DAE CRC64;
MIIGNIHNLQ PWLPQELRQA IEHIKAHVTA ETPKGKHDIE GNRLFYLISE DMTEPYEARR
AEYHARYLDI QIVLKGQEGM TFSTQPAGAP DTDWLADKDI AFLPEGVDEK TVILNEGDFV
VFYPGEVHKP LCAVGAPAQV RKAVVKMLMA
