ID   TABY5_TABYA             Reviewed;         256 AA.
AC   E0XKJ8;
DT   31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Allergen Tab y 5.0101 {ECO:0000303|PubMed:20608917};
DE   AltName: Full=Allergen Tab a 1 {ECO:0000303|PubMed:20608917};
DE   AltName: Full=Antigen 5-related protein {ECO:0000303|PubMed:20608917};
DE            Short=Ag 5 allergen {ECO:0000303|PubMed:20608917};
DE   AltName: Allergen=Tab y 5.0101 {ECO:0000303|PubMed:20608917};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572 {ECO:0000312|EMBL:ADM18345.1};
RN   [1] {ECO:0000312|EMBL:ADM18345.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-36; 123-136; 187-197 AND
RP   205-218, TISSUE SPECIFICITY, PYROGLUTAMATE FORMATION AT GLN-17, AND
RP   ALLERGEN.
RC   TISSUE=Salivary gland {ECO:0000303|PubMed:20608917,
RC   ECO:0000312|EMBL:ADM18345.1};
RX   PubMed=20608917; DOI=10.1111/j.1398-9995.2010.02435.x;
RA   Ma D., Li Y., Dong J., An S., Wang Y., Liu C., Yang X., Yang H., Xu X.,
RA   Lin D., Lai R.;
RT   "Purification and characterization of two new allergens from the salivary
RT   glands of the horsefly, Tabanus yao.";
RL   Allergy 66:101-109(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:20608917}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000269|PubMed:20608917}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 86.5%
CC       of the 37 patients tested allergic to horsefly bites. Has some binding
CC       capacity to IgE of patients with V.magnifica wasp sting allergy.
CC       {ECO:0000269|PubMed:20608917}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; GU321118; ADM18345.1; -; mRNA.
DR   AlphaFoldDB; E0XKJ8; -.
DR   SMR; E0XKJ8; -.
DR   Allergome; 8831; Tab y 5.
DR   Allergome; 9055; Tab y 5.0101.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Pyrrolidone carboxylic acid; Secreted;
KW   Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|PubMed:20608917"
FT   CHAIN           17..256
FT                   /note="Allergen Tab y 5.0101"
FT                   /evidence="ECO:0000305|PubMed:20608917"
FT                   /id="PRO_5003143078"
FT   DOMAIN          67..211
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         17
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:20608917"
SQ   SEQUENCE   256 AA;  28392 MW;  ACFCE7441C36D604 CRC64;
     MAPIIVPCLL LVVLVLQCSV INSLDYCSLC RGGRGEHVGC GSPGFSSDCG QKARTRKFTK
     EHKKVILDKI NDVRDHVAKG SWGLPVASRM KVIVWDEELA ALAKRHTQGC VPEAYKCRHT
     LRFWSPGQLN FEFYADKMPS TMSLISTAIK RGHTQKHNIT RDIIEKYQPA GPKGNVKELA
     LAISDRVTAV GCGLTTWKLG GKARALLTCN FSSENDYNRP VYKTGNSPGE KCIKKDETFK
     NLCSAQEPIN PNEHNF