TAC2N_HUMAN
ID TAC2N_HUMAN Reviewed; 490 AA.
AC Q8N9U0;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Tandem C2 domains nuclear protein;
DE AltName: Full=Membrane targeting tandem C2 domain-containing protein 1;
DE AltName: Full=Tandem C2 protein in nucleus;
DE Short=Tac2-N;
GN Name=TC2N; Synonyms=C14orf47, MTAC2D1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP THR-151.
RC TISSUE=Stomach cancer, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-151.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-211; THR-214;
RP THR-216 AND SER-218, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Platelet;
RX PubMed=18088087; DOI=10.1021/pr0704130;
RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT "Phosphoproteome of resting human platelets.";
RL J. Proteome Res. 7:526-534(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-156; SER-168 AND
RP SER-174, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N9U0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N9U0-2; Sequence=VSP_008572;
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DR EMBL; AK093876; BAC04238.1; -; mRNA.
DR EMBL; AK126359; BAC86538.1; -; mRNA.
DR EMBL; AL121839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040503; AAH40503.1; -; mRNA.
DR CCDS; CCDS73679.1; -. [Q8N9U0-2]
DR CCDS; CCDS9897.1; -. [Q8N9U0-1]
DR RefSeq; NP_001122067.1; NM_001128595.2. [Q8N9U0-1]
DR RefSeq; NP_001122068.1; NM_001128596.2. [Q8N9U0-1]
DR RefSeq; NP_001276063.1; NM_001289134.1. [Q8N9U0-2]
DR RefSeq; NP_689545.1; NM_152332.5. [Q8N9U0-1]
DR AlphaFoldDB; Q8N9U0; -.
DR SMR; Q8N9U0; -.
DR BioGRID; 125812; 16.
DR IntAct; Q8N9U0; 2.
DR STRING; 9606.ENSP00000387882; -.
DR iPTMnet; Q8N9U0; -.
DR PhosphoSitePlus; Q8N9U0; -.
DR SwissPalm; Q8N9U0; -.
DR BioMuta; TC2N; -.
DR DMDM; 317373282; -.
DR EPD; Q8N9U0; -.
DR jPOST; Q8N9U0; -.
DR MassIVE; Q8N9U0; -.
DR MaxQB; Q8N9U0; -.
DR PaxDb; Q8N9U0; -.
DR PeptideAtlas; Q8N9U0; -.
DR PRIDE; Q8N9U0; -.
DR ProteomicsDB; 72584; -. [Q8N9U0-1]
DR ProteomicsDB; 72585; -. [Q8N9U0-2]
DR Antibodypedia; 26667; 88 antibodies from 19 providers.
DR DNASU; 123036; -.
DR Ensembl; ENST00000340892.9; ENSP00000343199.5; ENSG00000165929.13. [Q8N9U0-1]
DR Ensembl; ENST00000360594.9; ENSP00000353802.5; ENSG00000165929.13. [Q8N9U0-1]
DR Ensembl; ENST00000435962.7; ENSP00000387882.2; ENSG00000165929.13. [Q8N9U0-1]
DR Ensembl; ENST00000556018.5; ENSP00000451317.1; ENSG00000165929.13. [Q8N9U0-2]
DR Ensembl; ENST00000610758.4; ENSP00000483305.1; ENSG00000276776.4. [Q8N9U0-1]
DR Ensembl; ENST00000620359.2; ENSP00000478127.2; ENSG00000276776.4. [Q8N9U0-1]
DR Ensembl; ENST00000632584.1; ENSP00000487608.1; ENSG00000276776.4. [Q8N9U0-1]
DR Ensembl; ENST00000634120.1; ENSP00000488431.1; ENSG00000276776.4. [Q8N9U0-2]
DR GeneID; 123036; -.
DR KEGG; hsa:123036; -.
DR MANE-Select; ENST00000435962.7; ENSP00000387882.2; NM_001128596.3; NP_001122068.2.
DR UCSC; uc001xzt.6; human. [Q8N9U0-1]
DR CTD; 123036; -.
DR DisGeNET; 123036; -.
DR GeneCards; TC2N; -.
DR HGNC; HGNC:19859; TC2N.
DR HPA; ENSG00000165929; Tissue enhanced (pancreas).
DR MIM; 619305; gene.
DR neXtProt; NX_Q8N9U0; -.
DR OpenTargets; ENSG00000165929; -.
DR PharmGKB; PA162405395; -.
DR VEuPathDB; HostDB:ENSG00000165929; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00390000009196; -.
DR HOGENOM; CLU_043542_0_0_1; -.
DR InParanoid; Q8N9U0; -.
DR OMA; PHRFMKR; -.
DR OrthoDB; 729490at2759; -.
DR PhylomeDB; Q8N9U0; -.
DR TreeFam; TF317035; -.
DR PathwayCommons; Q8N9U0; -.
DR SignaLink; Q8N9U0; -.
DR BioGRID-ORCS; 123036; 15 hits in 1073 CRISPR screens.
DR ChiTaRS; TC2N; human.
DR GeneWiki; TC2N; -.
DR GenomeRNAi; 123036; -.
DR Pharos; Q8N9U0; Tbio.
DR PRO; PR:Q8N9U0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8N9U0; protein.
DR Bgee; ENSG00000165929; Expressed in body of pancreas and 101 other tissues.
DR ExpressionAtlas; Q8N9U0; baseline and differential.
DR Genevisible; Q8N9U0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR CDD; cd08684; C2A_Tac2-N; 1.
DR CDD; cd08692; C2B_Tac2-N; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037786; C2A_Tac2-N.
DR InterPro; IPR037788; C2B_Tac2-N.
DR InterPro; IPR030542; Tac2-N.
DR PANTHER; PTHR46887; PTHR46887; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..490
FT /note="Tandem C2 domains nuclear protein"
FT /id="PRO_0000072414"
FT DOMAIN 223..342
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 344..471
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 189..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 447..449
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18088087,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 174
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18088087"
FT MOD_RES 214
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18088087"
FT MOD_RES 216
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18088087"
FT MOD_RES 218
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18088087"
FT VAR_SEQ 286..349
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_008572"
FT VARIANT 151
FT /note="K -> T (in dbSNP:rs2402073)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_051405"
FT VARIANT 172
FT /note="S -> N (in dbSNP:rs8020529)"
FT /id="VAR_051406"
FT CONFLICT 60
FT /note="D -> G (in Ref. 1; BAC86538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 490 AA; 55284 MW; 5606E022D6584200 CRC64;
MATEFIKSCC GGCFYGETEK HNFSVERDFK AAVPNSQNAT ISVPPLTSVS VKPQLGCTED
YLLSKLPSDG KEVPFVVPKF KLSYIQPRTQ ETPSHLEELE GSARASFGDR KVELSSSSQH
GPSYDVYNPF YMYQHISPDL SRRFPPRSEV KRLYGSVCDL RTNKLPGSPG LSKSMFDLTN
SSQRFIQRHD SLSSVPSSSS SRKNSQGSNR SLDTITLSGD ERDFGRLNVK LFYNSSVEQI
WITVLQCRDL SWPSSYGDTP TVSIKGILTL PKPVHFKSSA KEGSNAIEFM ETFVFAIKLQ
NLQTVRLVFK IQTQTPRKKT IGECSMSLRT LSTQEMDYSL DITPPSKISV CHAELELGTC
FQAVNSRIQL QILEARYLPS SSTPLTLSFF VKVGMFSSGE LIYKKKTRLL KASNGRVKWG
ETMIFPLIQS EKEIVFLIKL YSRSSVRRKH FVGQIWISED SNNIEAVNQW KETVINPEKV
VIRWHKLNPS
