TAC2N_MOUSE
ID TAC2N_MOUSE Reviewed; 489 AA.
AC Q91XT6; Q3UW74; Q9D4A0;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Tandem C2 domains nuclear protein;
DE AltName: Full=Membrane targeting tandem C2 domain-containing protein 1;
DE AltName: Full=Tandem C2 protein in nucleus;
DE Short=Tac2-N;
GN Name=Tc2n; Synonyms=Mtac2d1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP 446-LYS--LYS-448.
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=11526914; DOI=10.1016/s0014-5793(01)02738-7;
RA Fukuda M., Mikoshiba K.;
RT "Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus.";
RL FEBS Lett. 503:217-218(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11526914}.
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DR EMBL; AB062282; BAB62893.1; -; mRNA.
DR EMBL; AK016683; BAB30378.1; -; mRNA.
DR EMBL; AK136558; BAE23043.1; -; mRNA.
DR EMBL; CH466549; EDL18876.1; -; Genomic_DNA.
DR EMBL; BC120793; AAI20794.1; -; mRNA.
DR CCDS; CCDS36524.1; -.
DR RefSeq; NP_001076445.1; NM_001082976.2.
DR RefSeq; NP_083200.1; NM_028924.3.
DR RefSeq; XP_006516364.1; XM_006516301.3.
DR RefSeq; XP_006516366.1; XM_006516303.3.
DR RefSeq; XP_011242493.1; XM_011244191.2.
DR RefSeq; XP_011242494.1; XM_011244192.2.
DR RefSeq; XP_017170706.1; XM_017315217.1.
DR AlphaFoldDB; Q91XT6; -.
DR SMR; Q91XT6; -.
DR STRING; 10090.ENSMUSP00000125288; -.
DR iPTMnet; Q91XT6; -.
DR PhosphoSitePlus; Q91XT6; -.
DR PaxDb; Q91XT6; -.
DR PRIDE; Q91XT6; -.
DR ProteomicsDB; 262998; -.
DR Antibodypedia; 26667; 88 antibodies from 19 providers.
DR DNASU; 74413; -.
DR Ensembl; ENSMUST00000110047; ENSMUSP00000105674; ENSMUSG00000021187.
DR Ensembl; ENSMUST00000160830; ENSMUSP00000124287; ENSMUSG00000021187.
DR Ensembl; ENSMUST00000162735; ENSMUSP00000125288; ENSMUSG00000021187.
DR GeneID; 74413; -.
DR KEGG; mmu:74413; -.
DR UCSC; uc007otm.2; mouse.
DR CTD; 123036; -.
DR MGI; MGI:1921663; Tc2n.
DR VEuPathDB; HostDB:ENSMUSG00000021187; -.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00390000009196; -.
DR HOGENOM; CLU_043542_0_0_1; -.
DR InParanoid; Q91XT6; -.
DR OMA; PHRFMKR; -.
DR OrthoDB; 729490at2759; -.
DR PhylomeDB; Q91XT6; -.
DR TreeFam; TF317035; -.
DR BioGRID-ORCS; 74413; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q91XT6; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q91XT6; protein.
DR Bgee; ENSMUSG00000021187; Expressed in seminal vesicle and 98 other tissues.
DR ExpressionAtlas; Q91XT6; baseline and differential.
DR Genevisible; Q91XT6; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR CDD; cd08684; C2A_Tac2-N; 1.
DR CDD; cd08692; C2B_Tac2-N; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037786; C2A_Tac2-N.
DR InterPro; IPR037788; C2B_Tac2-N.
DR InterPro; IPR030542; Tac2-N.
DR PANTHER; PTHR46887; PTHR46887; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..489
FT /note="Tandem C2 domains nuclear protein"
FT /id="PRO_0000072415"
FT DOMAIN 222..341
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 343..470
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 189..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 446..448
FT /note="Nuclear localization signal"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 155
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 173
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 210
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 213
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 215
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MOD_RES 217
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9U0"
FT MUTAGEN 446..448
FT /note="RRK->QQQ: Abolishes nuclear localization."
FT /evidence="ECO:0000269|PubMed:11526914"
FT CONFLICT 35
FT /note="S -> N (in Ref. 1; BAB62893)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 54988 MW; CFBB3E069EB68D5A CRC64;
MAAEFIKSCC RGCLYGETEK QKFSVDRDFK ASASSSQNTI GIPPLTSVLV KPQVGCNEDY
LLSKLPCDGK EVQFVVPRFK LSYIQPRTQG IPSHLDELEG SARASFGDQK TELCSSFYHG
PSYDVYNPCY MYQHFSPDLS RRFLPHCETK QLYGSVCDLR TSKLPGSSGL SKSMLDLTTS
SQRFIQRHDS FSSVPSSSSS RKNSQGSNRS LDTITLSGDE RDLGRLNVKL FYNSSAEQIW
ITVLQCRDIS WPSSYGDTPT ISIKGILTLS KPVHFKSSAK EGSNAIEFME TFVFAIKLQN
LQAVRLAFKI QTQTPKKKTI GECSLSLRTL STQEMEYSLE IIAPSKISVC QAELELGTCF
QAVNSRIQLQ ILEAQYLPSS STPLTLSFFV KVGMFSSGEL IYKKKTRLLK ASSGRVKWGE
TMIFPLIQTE KEIVFLIKLY SRSSVRRKHF VGQLWISEDS NNIEAVNQWK ETITNPEKVV
IKWHKLNPS
