ID   TAC3_TACGI              Reviewed;          17 AA.
AC   P18252;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Tachyplesin-3;
DE   AltName: Full=Tachyplesin III;
OS   Tachypleus gigas (Southeast Asian horseshoe crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
OC   Xiphosura; Limulidae; Tachypleus.
OX   NCBI_TaxID=6852;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ARG-17.
RX   PubMed=2229025; DOI=10.1093/oxfordjournals.jbchem.a123191;
RA   Muta T., Fujimoto T., Nakajima H., Iwanaga S.;
RT   "Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs
RT   (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a
RT   new tachyplesin, tachyplesin III, and a processing intermediate of its
RT   precursor.";
RL   J. Biochem. 108:261-266(1990).
CC   -!- FUNCTION: Significantly inhibits the growth of Gram-negative and Gram-
CC       positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Hemocytes.
CC   -!- SIMILARITY: Belongs to the tachyplesin/polyphemusin family.
CC       {ECO:0000305}.
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DR   PIR; JX0125; JX0125.
DR   PDB; 6PI3; NMR; -; A=1-17.
DR   PDB; 6PIP; NMR; -; A=1-17.
DR   PDBsum; 6PI3; -.
DR   PDBsum; 6PIP; -.
DR   AlphaFoldDB; P18252; -.
DR   BMRB; P18252; -.
DR   SMR; P18252; -.
DR   PRIDE; P18252; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..17
FT                   /note="Tachyplesin-3"
FT                   /id="PRO_0000044451"
FT   MOD_RES         17
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000269|PubMed:2229025"
FT   DISULFID        3..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..12
FT                   /evidence="ECO:0000250"
FT   STRAND          3..8
FT                   /evidence="ECO:0007829|PDB:6PI3"
FT   STRAND          11..16
FT                   /evidence="ECO:0007829|PDB:6PI3"
SQ   SEQUENCE   17 AA;  2241 MW;  E9E08CE9D2923C94 CRC64;
     KWCFRVCYRG ICYRKCR