ID   TACAN_DANRE             Reviewed;         341 AA.
AC   A3KNK1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Ion channel TACAN {ECO:0000250|UniProtKB:Q8C1E7};
DE   AltName: Full=Transmembrane protein 120A {ECO:0000305};
GN   Name=tmem120a {ECO:0000250|UniProtKB:Q8C1E7};
GN   ORFNames=zgc:162139 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ion channel involved in sensing mechanical pain. Contributes
CC       to mechanosensitive currents in nocireceptors and detecting mechanical
CC       pain stimuli. May also be required for efficient adipogenesis.
CC       {ECO:0000250|UniProtKB:Q8C1E7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C1E7};
CC       Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC133884; AAI33885.1; -; mRNA.
DR   RefSeq; NP_001076452.1; NM_001082983.1.
DR   AlphaFoldDB; A3KNK1; -.
DR   SMR; A3KNK1; -.
DR   STRING; 7955.ENSDARP00000048830; -.
DR   PaxDb; A3KNK1; -.
DR   Ensembl; ENSDART00000048831; ENSDARP00000048830; ENSDARG00000030914.
DR   GeneID; 100005623; -.
DR   KEGG; dre:100005623; -.
DR   CTD; 100005623; -.
DR   ZFIN; ZDB-GENE-070424-21; tmem120aa.
DR   eggNOG; KOG4758; Eukaryota.
DR   GeneTree; ENSGT00390000007848; -.
DR   HOGENOM; CLU_048749_1_1_1; -.
DR   InParanoid; A3KNK1; -.
DR   OMA; TVNCALL; -.
DR   OrthoDB; 916768at2759; -.
DR   PhylomeDB; A3KNK1; -.
DR   TreeFam; TF313552; -.
DR   PRO; PR:A3KNK1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000030914; Expressed in testis and 21 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005216; F:ion channel activity; ISS:UniProtKB.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; ISS:UniProtKB.
DR   GO; GO:0045444; P:fat cell differentiation; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..341
FT                   /note="Ion channel TACAN"
FT                   /id="PRO_0000309527"
FT   TOPO_DOM        1..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..161
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        162..182
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..189
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..221
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        222..244
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..272
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..307
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        308..328
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..341
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   341 AA;  40684 MW;  F8B5893C4FA86B10 CRC64;
     MLFNPTGLTE CLQEWEDLEK DYQQIQDTHR HYKHKLEEVS KLQESCSSSI ARQRKKLKDL
     SESLEECKGA VNPEDVNKID DIQESIKERP NVFFEMEAFL PKKNGLYLSL VLGNVNVTLL
     NKQSKFAYKD EYEKFKLYLT VLLLFFSFTC RFLVSYRVVD ALFNFLLVWY YCTLTIRESI
     LINNGSKIKG WWVFQHYVST FLSGVMLTWP DGELYQMFRN QFLSYSMYIN FVQFFQYYYQ
     SGCLYRLRAL GERHNMDLTV EGFQSWMWRG LTFLLPFLFL GHFFQLYNGI TLFQMTQLPE
     WKEWQVLMCG STFLVLFMGN FFTTLGVVYH KYMDQDKAKG L