ID   TACAN_RAT               Reviewed;         343 AA.
AC   Q5HZE2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Ion channel TACAN {ECO:0000250|UniProtKB:Q8C1E7};
DE   AltName: Full=Transmembrane protein 120A {ECO:0000305};
GN   Name=Tmem120a {ECO:0000312|RGD:1311474};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Ion channel involved in sensing mechanical pain. Contributes
CC       to mechanosensitive currents in nocireceptors and detecting mechanical
CC       pain stimuli. May also be required for efficient adipogenesis.
CC       {ECO:0000250|UniProtKB:Q8C1E7}.
CC   -!- SUBUNIT: Homooligomer and heterooligomer with TMEM120B.
CC       {ECO:0000250|UniProtKB:Q8C1E7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C1E7};
CC       Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC089063; AAH89063.1; -; mRNA.
DR   RefSeq; NP_001010945.1; NM_001010945.1.
DR   AlphaFoldDB; Q5HZE2; -.
DR   SMR; Q5HZE2; -.
DR   STRING; 10116.ENSRNOP00000001960; -.
DR   PhosphoSitePlus; Q5HZE2; -.
DR   jPOST; Q5HZE2; -.
DR   PaxDb; Q5HZE2; -.
DR   PRIDE; Q5HZE2; -.
DR   Ensembl; ENSRNOT00000115876; ENSRNOP00000085652; ENSRNOG00000001441.
DR   GeneID; 288591; -.
DR   KEGG; rno:288591; -.
DR   UCSC; RGD:1311474; rat.
DR   CTD; 83862; -.
DR   RGD; 1311474; Tmem120a.
DR   eggNOG; KOG4758; Eukaryota.
DR   GeneTree; ENSGT00390000007848; -.
DR   HOGENOM; CLU_048749_1_1_1; -.
DR   InParanoid; Q5HZE2; -.
DR   OMA; TVNCALL; -.
DR   OrthoDB; 916768at2759; -.
DR   PhylomeDB; Q5HZE2; -.
DR   TreeFam; TF313552; -.
DR   PRO; PR:Q5HZE2; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001441; Expressed in jejunum and 18 other tissues.
DR   Genevisible; Q5HZE2; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005216; F:ion channel activity; ISS:UniProtKB.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; ISS:UniProtKB.
DR   GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0034220; P:ion transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0051291; P:protein heterooligomerization; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..343
FT                   /note="Ion channel TACAN"
FT                   /id="PRO_0000309341"
FT   TOPO_DOM        1..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        136..156
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..190
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        191..211
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..222
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        223..240
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        274..294
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..305
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        306..326
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..343
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   343 AA;  40657 MW;  9949CE5A59B3912C CRC64;
     MQSPPPDPLG DCLRNWEDLQ QDFQGIQETH RLYRVKLEEL TKLQDNCTNS ITRQKKRLQE
     LALVLKKCRP SLPSESLEAA QELESQIKER QGLFFDMEAY LPKKNGLYLS LVLGNVNVTL
     LSKQAKFAYK DEYEKFKLYL TIILIVISFT CRFLLNSRVT DAAFNFLLVW YYCTLTIRES
     ILINNGSRIK GWWVFHHYVS TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY
     QSGCLYRLRA LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
     ECKEWQVLMC GLPFLLLFLG NFFTTLRVVH QKFHSQQHGS KKD