ID   TACAN_XENLA             Reviewed;         336 AA.
AC   A1L2R7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Ion channel TACAN {ECO:0000250|UniProtKB:Q8C1E7};
DE   AltName: Full=Transmembrane protein 120A {ECO:0000305};
GN   Name=tmem120a {ECO:0000250|UniProtKB:Q8C1E7};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryonic tail;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ion channel involved in sensing mechanical pain. Contributes
CC       to mechanosensitive currents in nocireceptors and detecting mechanical
CC       pain stimuli. May also be required for efficient adipogenesis.
CC       {ECO:0000250|UniProtKB:Q8C1E7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C1E7};
CC       Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC129679; AAI29680.1; -; mRNA.
DR   RefSeq; NP_001091170.1; NM_001097701.1.
DR   AlphaFoldDB; A1L2R7; -.
DR   SMR; A1L2R7; -.
DR   DNASU; 100036930; -.
DR   GeneID; 100036930; -.
DR   KEGG; xla:100036930; -.
DR   CTD; 100036930; -.
DR   Xenbase; XB-GENE-5858597; tmem120a.L.
DR   OMA; TVNCALL; -.
DR   OrthoDB; 916768at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 100036930; Expressed in stomach and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005216; F:ion channel activity; ISS:UniProtKB.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; ISS:UniProtKB.
DR   GO; GO:0034220; P:ion transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..336
FT                   /note="Ion channel TACAN"
FT                   /id="PRO_0000309342"
FT   TOPO_DOM        1..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..161
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        162..182
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..189
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..221
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        222..239
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..272
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        305..325
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..336
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   336 AA;  40324 MW;  052EA219A36146C9 CRC64;
     MNSPVLQDCV REWGEIQENY QDIQETHRLY KQKLEELSKL QTRCSGTISR QKKKLRELSV
     ELKKCKSKAK NVEEEEEQIR DLNNQIRARE KTFFEMESFL PKKNGLYLSL VLGNVNVTLL
     SKQAKFAYKD EYEKFKLYLT IILMVLSFIC RFLLNSRVTD AVFNFLLVWY YCTLTIRESI
     LINNGSRIKG WWVLNHYIST FLSGVMLTWP DGLMYQMFRN QFLSFSMYQS FVQFLQYYYQ
     SGCLYRLRAL GERHNMDLTV EGFQSWMWRG LTFLLPFLFF GQFWQLYNAI TLFKLARHPE
     CKEWQVIMCG LPFLVHFLGN FFTTLRVVHQ KFQKQN