TACHY_AGRIP
ID TACHY_AGRIP Reviewed; 251 AA.
AC C0HKW2; C0HKW3; C0HKW4; C0HKW5; C0HKW6;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Tachykinins {ECO:0000305};
DE Contains:
DE RecName: Full=Tachykinin-related peptide 1 {ECO:0000303|PubMed:29466015};
DE Short=TK-1 {ECO:0000303|PubMed:29466015};
DE AltName: Full=VPQGFLGMR-amide {ECO:0000305};
DE Contains:
DE RecName: Full=Tachykinin-related peptide 2 {ECO:0000303|PubMed:29466015};
DE Short=TK-2 {ECO:0000303|PubMed:29466015};
DE AltName: Full=KPQFFVGVK-amide {ECO:0000305};
DE Contains:
DE RecName: Full=Tachykinin-related peptide 4 {ECO:0000303|PubMed:29466015};
DE Short=TK-4 {ECO:0000303|PubMed:29466015};
DE AltName: Full=AANFNQFYGVR-amide {ECO:0000305};
DE Contains:
DE RecName: Full=Tachykinin-related peptide 5 {ECO:0000303|PubMed:29466015};
DE Short=TK-5 {ECO:0000303|PubMed:29466015};
DE AltName: Full=PYDLTFRGKFIGVR-amide {ECO:0000305};
DE Contains:
DE RecName: Full=Tachykinin-related peptide 6 {ECO:0000303|PubMed:29466015};
DE Short=TK-6 {ECO:0000303|PubMed:29466015};
DE AltName: Full=KAQMGFFGMR-amide {ECO:0000305};
DE Flags: Precursor;
OS Agrotis ipsilon (Black cutworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Noctuinae; Noctuini; Agrotis.
OX NCBI_TaxID=56364;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-35; 53-61; 166-174;
RP 186-199 AND 226-235, TISSUE SPECIFICITY, MASS SPECTROMETRY, IDENTIFICATION
RP BY MASS SPECTROMETRY, AND AMIDATION AT ARG-36; LYS-61; ARG-176; ARG-199 AND
RP ARG-235.
RX PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA Schachtner J., Jacquin-Joly E., Gadenne C.;
RT "Mating-induced differential peptidomics of neuropeptides and protein
RT hormones in Agrotis ipsilon moths.";
RL J. Proteome Res. 17:1397-1414(2018).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles.
CC {ECO:0000250|UniProtKB:Q9VGE8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Tachykinin-related peptide 1: Expressed in antennal
CC lobe (AL) and gnathal ganglion (GNG) (at protein level). Expression in
CC AL detected in all animals, in GNG in most animals (at protein level).
CC Not expressed in corpora cardiaca (CC) and corpora allata (CA) (at
CC protein level). Tachykinin-related peptide 2: Expressed in antennal
CC lobe (AL) corpora cardiaca (CC) and corpora allata (CA) with expression
CC detected in few animals (at protein level). Not expressed in gnathal
CC ganglion (GNG) (at protein level). Tachykinin-related peptide 4:
CC Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe
CC (AL) and gnathal ganglion (GNG) (at protein level). Expression in AL
CC and GNG detected in most animals, in CC and CA detected in few animals
CC (at protein level). Tachykinin-related peptide 5: Expressed in corpora
CC cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal
CC ganglion (GNG) (at protein level). Expression in CC and CA detected in
CC some animals, in AL and GNG in few animals (at protein level).
CC Tachykinin-related peptide 6: Expressed in antennal lobe (AL) and
CC gnathal ganglion (GNG) (at protein level). Expression in AL detected in
CC all animals, in GNG in some animals (at protein level). Not expressed
CC in corpora cardiaca (CC) and corpora allata (CA) (at protein level).
CC {ECO:0000269|PubMed:29466015}.
CC -!- MASS SPECTROMETRY: [Tachykinin-related peptide 1]: Mass=1003.55;
CC Method=MALDI; Note=Tachykinin-related peptide 1.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Tachykinin-related peptide 2]: Mass=1048.62;
CC Method=MALDI; Note=Tachykinin-related peptide 2.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Tachykinin-related peptide 4]: Mass=1285.64;
CC Method=MALDI; Note=Tachykinin-related peptide 4.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Tachykinin-related peptide 5]: Mass=1667.92;
CC Method=MALDI; Note=Tachykinin-related peptide 5.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Tachykinin-related peptide 6]: Mass=1171.58;
CC Method=MALDI; Note=Tachykinin-related peptide 6.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR AlphaFoldDB; C0HKW2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..25
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444283"
FT PEPTIDE 28..36
FT /note="Tachykinin-related peptide 1"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444284"
FT PROPEP 39..50
FT /evidence="ECO:0000305"
FT /id="PRO_0000444285"
FT PEPTIDE 53..61
FT /note="Tachykinin-related peptide 2"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444286"
FT PROPEP 65..163
FT /evidence="ECO:0000305"
FT /id="PRO_0000444287"
FT PEPTIDE 166..176
FT /note="Tachykinin-related peptide 4"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444288"
FT PROPEP 180..183
FT /evidence="ECO:0000305"
FT /id="PRO_0000444289"
FT PEPTIDE 186..199
FT /note="Tachykinin-related peptide 5"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444290"
FT PROPEP 203..223
FT /evidence="ECO:0000305"
FT /id="PRO_0000444291"
FT PEPTIDE 226..235
FT /note="Tachykinin-related peptide 6"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444292"
FT PROPEP 239..251
FT /evidence="ECO:0000305"
FT /id="PRO_0000444293"
FT MOD_RES 36
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 61
FT /note="Lysine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 176
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 199
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 235
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
SQ SEQUENCE 251 AA; 28785 MW; 2BEE80B1BACB50F7 CRC64;
MGAPRTCLIF ITIQLVSLAY AQEVSKRVPQ GFLGMRGKKY FDEEGIEQFY KRKPQFFVGV
KGKKSLQDIL EAPEEYYKRA PMGFMGMRGK KDLGDSQSTE LFPKRDGSLI GKIDYSSKEE
NADPDFPILN ELLLQYLSQL DAPRNTYMQS SESMEPEQSN DLDKRAANFN QFYGVRGKKS
INNKRPYDLT FRGKFIGVRG KKDLKNSNAH EIKFLVDQNG PLPKRKAQMG FFGMRGKKWT
DEPSLEMDMP N
