TACHY_CAMFO
ID TACHY_CAMFO Reviewed; 426 AA.
AC E2AIS8;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Tachykinins {ECO:0000312|EMBL:EFN66667.1};
DE Contains:
DE RecName: Full=APMGFQGMR-amide {ECO:0000305};
DE AltName: Full=Tachykinin-related peptide 1 {ECO:0000303|PubMed:25641051};
DE Contains:
DE RecName: Full=TIMGFQGMR-amide {ECO:0000305};
DE AltName: Full=Tachykinin-related peptide 2 {ECO:0000303|PubMed:25641051};
DE Contains:
DE RecName: Full=SPFRYFEMR-amide {ECO:0000305};
DE AltName: Full=Tachykinin-related peptide 3 {ECO:0000303|PubMed:25641051};
DE Contains:
DE RecName: Full=NPRWELRGMFVGVR-amide {ECO:0000305};
DE AltName: Full=Tachykinin-related peptide 4 {ECO:0000303|PubMed:25641051};
GN ORFNames=EAG_05065 {ECO:0000312|EMBL:EFN66667.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 119-127; 148-156; 170-178; 238-246; 262-270; 294-302;
RP 311-319; 361-369 AND 373-386, TISSUE SPECIFICITY, MASS SPECTROMETRY,
RP IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT ARG-127; ARG-156;
RP ARG-178; ARG-246; ARG-270; ARG-302; ARG-319; ARG-369 AND ARG-386.
RX PubMed=25641051; DOI=10.1021/pr5011636;
RA Schmitt F., Vanselow J.T., Schlosser A., Kahnt J., Roessler W., Wegener C.;
RT "Neuropeptidomics of the carpenter ant Camponotus floridanus.";
RL J. Proteome Res. 14:1504-1514(2015).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles.
CC {ECO:0000250|UniProtKB:Q868G6}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25641051}.
CC -!- TISSUE SPECIFICITY: Tachykinins (TK) are expressed throughout the
CC nervous system. APMGFQGMR-amide is also expressed in the retrocerebral
CC complex (at protein level). {ECO:0000269|PubMed:25641051}.
CC -!- MASS SPECTROMETRY: [APMGFQGMR-amide]: Mass=993.48; Method=Electrospray;
CC Note=APMGFQGMR-amide.; Evidence={ECO:0000269|PubMed:25641051};
CC -!- MASS SPECTROMETRY: [TIMGFQGMR-amide]: Mass=1039.52;
CC Method=Electrospray; Note=TIMGFQGMR-amide.;
CC Evidence={ECO:0000269|PubMed:25641051};
CC -!- MASS SPECTROMETRY: [SPFRYFEMR-amide]: Mass=1231.6; Method=Electrospray;
CC Note=SPFRYFEMR-amide.; Evidence={ECO:0000269|PubMed:25641051};
CC -!- MASS SPECTROMETRY: [NPRWELRGMFVGVR-amide]: Mass=1715.93;
CC Method=Electrospray; Note=NPRWELRGMFVGVR-amide.;
CC Evidence={ECO:0000269|PubMed:25641051};
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR EMBL; GL439874; EFN66667.1; -; Genomic_DNA.
DR AlphaFoldDB; E2AIS8; -.
DR STRING; 104421.E2AIS8; -.
DR InParanoid; E2AIS8; -.
DR OMA; EYYKRAP; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted.
FT PROPEP 1..116
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434164"
FT PEPTIDE 119..127
FT /note="APMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434165"
FT PROPEP 131..145
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434166"
FT PEPTIDE 148..156
FT /note="APMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434167"
FT PROPEP 160..167
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434168"
FT PEPTIDE 170..178
FT /note="APMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434169"
FT PROPEP 182..235
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434170"
FT PEPTIDE 238..246
FT /note="APMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434171"
FT PROPEP 250..259
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434172"
FT PEPTIDE 262..270
FT /note="TIMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434173"
FT PROPEP 274..291
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434174"
FT PEPTIDE 294..302
FT /note="APMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434175"
FT PROPEP 306..308
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434176"
FT PEPTIDE 311..319
FT /note="APMGFQGMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434177"
FT PROPEP 323..358
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434178"
FT PEPTIDE 361..369
FT /note="SPFRYFEMR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434179"
FT PEPTIDE 373..386
FT /note="NPRWELRGMFVGVR-amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434180"
FT PROPEP 390..426
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434181"
FT REGION 299..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 127
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 156
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 178
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 246
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 270
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 302
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 319
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 369
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
FT MOD_RES 386
FT /note="Arginine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
SQ SEQUENCE 426 AA; 49591 MW; 2C7D3BE060657DB4 CRC64;
MQCDFRVHQD ARLARVYYFT EVWWMFIFKF LEPKMLINSV LFLAIWSSSF AEESSSSDAT
SNKRAAMGFQ DMRGNKNLIP TSLEHNKLSK RTLMDFQDNK DSNAPDIEDN LSHEFEKRAP
MGFQGMRGKK GYLTPDFEDS YFRDEKRAPM GFQGMRGKKV VSDDDYYKRA PMGFQGMRGK
KSLEEVLGEI EKKAAMDYYD TRDKKTYVFE YPEDYEKRLL ASIRGKLKEF PMEWEKRAPM
GFQGMRGKKS LLDEIEELEK RTIMGFQGMR GKKNALENYI DYYLDPDMDF DKRAPMGFQG
MRGKKDSDKR APMGFQGMRG KRNTGQRFDT GINFNIRSSN EYQGTNNRRN ALASCQLEKR
SPFRYFEMRG KKNPRWELRG MFVGVRGKKW ATAPYEDDSP FISVFDNTER IGVDGDSPAI
LGNSIS
