TACHY_DROPS
ID TACHY_DROPS Reviewed; 289 AA.
AC Q295T3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 3.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=Tachykinins;
DE Contains:
DE RecName: Full=Tachykinin-related peptide 1;
DE Short=TK-1;
DE AltName: Full=APTSSFIGMR-amide;
DE Contains:
DE RecName: Full=Tachykinin-associated peptide 1;
DE Short=TAP1;
DE AltName: Full=EDEKDQRAADWMGPDPLDYADMDEDSIYYEN-amide;
DE Contains:
DE RecName: Full=Tachykinin-related peptide 2;
DE Short=TK-2;
DE AltName: Full=APMSFVGMR-amide;
DE Contains:
DE RecName: Full=Tachykinin-associated peptide 2;
DE Short=TAP2;
DE AltName: Full=YIPISNRLSDVLHQIEEQRMRENLLEDLFERLAAGDDSVGDV-amide;
DE Contains:
DE RecName: Full=Tachykinin-related peptide 3;
DE Short=TK-3;
DE AltName: Full=APTGFTGMR-amide;
DE Contains:
DE RecName: Full=Tachykinin-associated peptide 3;
DE Short=TAP3;
DE AltName: Full=Brain peptide PMSGDDDDNDAMELLQ;
DE Contains:
DE RecName: Full=Tachykinin-related peptide 4;
DE Short=TK-4;
DE AltName: Full=APVNSFLGVR-amide;
DE Contains:
DE RecName: Full=Tachykinin-associated peptide 4;
DE Short=TAP4;
DE AltName: Full=Brain peptide DVSHQHY;
DE Contains:
DE RecName: Full=Tachykinin-associated peptide 5;
DE Short=TAP5;
DE AltName: Full=AALSEAYDVRGKKERYADFNSKFVAVR-amide;
DE Contains:
DE RecName: Full=Tachykinin-associated peptide 6;
DE Short=TAP6;
DE AltName: Full=Brain peptide SEQEAGLDTGDGDGDQQYLVRPWLYLWADN;
DE Contains:
DE RecName: Full=Tachykinin-related peptide 5;
DE Short=TK-5;
DE AltName: Full=APSGFQGMR-amide;
DE Flags: Precursor;
GN Name=Tk {ECO:0000250|UniProtKB:Q9VGE8}; ORFNames=GA13208;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles. Stimulates gut
CC muscle contractions (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL28625.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM000070; EAL28625.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015037927.1; XM_015182441.1.
DR AlphaFoldDB; Q295T3; -.
DR STRING; 7237.FBpp0281478; -.
DR EnsemblMetazoa; FBtr0375568; FBpp0336948; FBgn0073245.
DR GeneID; 4802586; -.
DR KEGG; dpo:Dpse_GA13208; -.
DR eggNOG; ENOG502S9VB; Eukaryota.
DR InParanoid; Q295T3; -.
DR ChiTaRS; Tk; fly.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0073245; Expressed in insect adult head and 2 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0060450; P:positive regulation of hindgut contraction; ISS:UniProtKB.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..49
FT /evidence="ECO:0000255"
FT /id="PRO_0000343501"
FT PEPTIDE 52..61
FT /note="Tachykinin-related peptide 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343502"
FT PEPTIDE 65..95
FT /note="Tachykinin-associated peptide 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343503"
FT PEPTIDE 102..110
FT /note="Tachykinin-related peptide 2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343504"
FT PEPTIDE 114..155
FT /note="Tachykinin-associated peptide 2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343505"
FT PEPTIDE 159..167
FT /note="Tachykinin-related peptide 3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343506"
FT PEPTIDE 171..186
FT /note="Tachykinin-associated peptide 3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343507"
FT PEPTIDE 189..198
FT /note="Tachykinin-related peptide 4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343508"
FT PEPTIDE 202..208
FT /note="Tachykinin-associated peptide 4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343509"
FT PEPTIDE 211..237
FT /note="Tachykinin-associated peptide 5"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343510"
FT PEPTIDE 241..270
FT /note="Tachykinin-associated peptide 6"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343511"
FT PEPTIDE 273..281
FT /note="Tachykinin-related peptide 5"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343512"
FT PROPEP 285..289
FT /evidence="ECO:0000255"
FT /id="PRO_0000343513"
FT REGION 28..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="Arginine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 95
FT /note="Asparagine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 110
FT /note="Arginine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 155
FT /note="Valine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 167
FT /note="Arginine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 198
FT /note="Arginine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 237
FT /note="Arginine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 281
FT /note="Arginine amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 289 AA; 32066 MW; D63CC1D092CEC6F4 CRC64;
MRSQGGSFAV ALLLLLLLTA AATAADAEPD VESSVSTLPP GADAPRRMVK RAPTSSFIGM
RGKKEDEKDQ RAADWMGPDP LDYADMDEDS IYYENGKRLK KAPMSFVGMR GKKYIPISNR
LSDVLHQIEE QRMRENLLED LFERLAAGDD SVGDVGKRAP TGFTGMRGKR PMSGDDDDND
AMELLQKRAP VNSFLGVRGK KDVSHQHYKR AALSEAYDVR GKKERYADFN SKFVAVRGKK
SEQEAGLDTG DGDGDQQYLV RPWLYLWADN KRAPSGFQGM RGKRPALAE
