TACO1_MOUSE
ID TACO1_MOUSE Reviewed; 294 AA.
AC Q8K0Z7; B1AR86; Q3TI86; Q3USS8; Q9CV09;
DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Translational activator of cytochrome c oxidase 1;
DE AltName: Full=Coiled-coil domain-containing protein 44;
DE AltName: Full=Translational activator of mitochondrially-encoded cytochrome c oxidase 1;
GN Name=Taco1; Synonyms=Ccdc44;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J;
RC TISSUE=Cerebellum, Corpora quadrigemina, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-162, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT identifies substrates of SIRT3 in metabolic pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
CC -!- FUNCTION: Acts as a translational activator of mitochondrially-encoded
CC cytochrome c oxidase 1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TACO1 family. {ECO:0000305}.
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DR EMBL; AK010072; BAB26682.1; -; mRNA.
DR EMBL; AK047078; BAC32953.1; -; mRNA.
DR EMBL; AK140143; BAE24253.1; -; mRNA.
DR EMBL; AK167963; BAE39960.1; -; mRNA.
DR EMBL; AL596331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029182; AAH29182.1; -; mRNA.
DR CCDS; CCDS25547.1; -.
DR RefSeq; NP_081622.1; NM_027346.1.
DR PDB; 5EKZ; X-ray; 2.00 A; A=1-294.
DR PDBsum; 5EKZ; -.
DR AlphaFoldDB; Q8K0Z7; -.
DR SMR; Q8K0Z7; -.
DR BioGRID; 213915; 5.
DR STRING; 10090.ENSMUSP00000002048; -.
DR iPTMnet; Q8K0Z7; -.
DR PhosphoSitePlus; Q8K0Z7; -.
DR SwissPalm; Q8K0Z7; -.
DR EPD; Q8K0Z7; -.
DR jPOST; Q8K0Z7; -.
DR MaxQB; Q8K0Z7; -.
DR PaxDb; Q8K0Z7; -.
DR PeptideAtlas; Q8K0Z7; -.
DR PRIDE; Q8K0Z7; -.
DR ProteomicsDB; 254643; -.
DR Antibodypedia; 18674; 180 antibodies from 26 providers.
DR DNASU; 70207; -.
DR Ensembl; ENSMUST00000002048; ENSMUSP00000002048; ENSMUSG00000001983.
DR GeneID; 70207; -.
DR KEGG; mmu:70207; -.
DR UCSC; uc007lyb.1; mouse.
DR CTD; 51204; -.
DR MGI; MGI:1917457; Taco1.
DR VEuPathDB; HostDB:ENSMUSG00000001983; -.
DR eggNOG; KOG2972; Eukaryota.
DR GeneTree; ENSGT00390000012820; -.
DR HOGENOM; CLU_062974_3_0_1; -.
DR InParanoid; Q8K0Z7; -.
DR OMA; ETIMYEG; -.
DR OrthoDB; 1199273at2759; -.
DR PhylomeDB; Q8K0Z7; -.
DR TreeFam; TF300070; -.
DR Reactome; R-MMU-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-9707564; Cytoprotection by HMOX1.
DR BioGRID-ORCS; 70207; 5 hits in 71 CRISPR screens.
DR PRO; PR:Q8K0Z7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8K0Z7; protein.
DR Bgee; ENSMUSG00000001983; Expressed in quadriceps femoris and 96 other tissues.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0097177; F:mitochondrial ribosome binding; IDA:MGI.
DR GO; GO:0003729; F:mRNA binding; IDA:MGI.
DR GO; GO:0019843; F:rRNA binding; IDA:MGI.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:MGI.
DR GO; GO:0061743; P:motor learning; IMP:MGI.
DR GO; GO:1904959; P:regulation of cytochrome-c oxidase activity; IMP:MGI.
DR GO; GO:0070129; P:regulation of mitochondrial translation; IMP:MGI.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.70.980; -; 2.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR002876; Transcrip_reg_TACO1-like.
DR InterPro; IPR026564; Transcrip_reg_TACO1-like_dom3.
DR InterPro; IPR029072; YebC-like.
DR PANTHER; PTHR12532; PTHR12532; 1.
DR Pfam; PF01709; Transcrip_reg; 1.
DR SUPFAM; SSF75625; SSF75625; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Activator; Coiled coil; Mitochondrion;
KW Reference proteome; Translation regulation.
FT CHAIN 1..294
FT /note="Translational activator of cytochrome c oxidase 1"
FT /id="PRO_0000175943"
FT COILED 190..224
FT /evidence="ECO:0000255"
FT MOD_RES 162
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT CONFLICT 86
FT /note="R -> G (in Ref. 1; BAE39960)"
FT /evidence="ECO:0000305"
FT HELIX 75..92
FT /evidence="ECO:0007829|PDB:5EKZ"
FT TURN 96..98
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 100..111
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 116..123
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 129..138
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 144..152
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 154..167
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 180..191
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 200..210
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 213..219
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 225..232
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 233..235
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 236..245
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 250..261
FT /evidence="ECO:0007829|PDB:5EKZ"
FT HELIX 267..282
FT /evidence="ECO:0007829|PDB:5EKZ"
FT STRAND 286..291
FT /evidence="ECO:0007829|PDB:5EKZ"
SQ SEQUENCE 294 AA; 32314 MW; 8285D9FE52E7AA1B CRC64;
MMSWAAASLR MTAVPCFRVR CLGFRVGPWG ASQHANPGCG AAPHRTLHVS ATASAGHNKW
SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS SLANILELCR SKNMPKSTIE
SALKTEKNKG IYLLYEGRGP GGSSLLIEAL SNSGPKCHLD IKYILNKNGG MMAEGARHFF
DKKGVVVVGV EDREKKAVNL ERALELAIEA GAEDVKEAED EEEKNLFKFI CDASSLHQVR
KKLDSLGLCP VSCSMEFIPH SKVQLAEPEL EQAAHLIQAL NNYEDVIHVY DNIE
