ID   TACO1_RAT               Reviewed;         295 AA.
AC   B2RYT9;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Translational activator of cytochrome c oxidase 1 {ECO:0000250|UniProtKB:Q9BSH4};
DE   AltName: Full=Coiled-coil domain-containing protein 44 {ECO:0000312|EMBL:AAI66900.1};
DE   AltName: Full=Translational activator of mitochondrially-encoded cytochrome c oxidase I {ECO:0000250|UniProtKB:Q9BSH4};
GN   Name=Taco1 {ECO:0000250|UniProtKB:Q9BSH4};
GN   Synonyms=Ccdc44 {ECO:0000312|EMBL:AAI66900.1, ECO:0000312|RGD:1306784};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:EDM06355.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000312|EMBL:EDM06355.1};
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAI66900.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary {ECO:0000312|EMBL:AAI66900.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as a translational activator of mitochondrially-encoded
CC       cytochrome c oxidase 1. {ECO:0000250|UniProtKB:Q9BSH4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BSH4}.
CC   -!- SIMILARITY: Belongs to the TACO1 family. {ECO:0000255}.
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DR   EMBL; CH473948; EDM06355.1; -; Genomic_DNA.
DR   EMBL; BC166900; AAI66900.1; -; mRNA.
DR   RefSeq; NP_001101772.1; NM_001108302.1.
DR   AlphaFoldDB; B2RYT9; -.
DR   SMR; B2RYT9; -.
DR   STRING; 10116.ENSRNOP00000061257; -.
DR   PeptideAtlas; B2RYT9; -.
DR   PRIDE; B2RYT9; -.
DR   Ensembl; ENSRNOT00000063973; ENSRNOP00000061257; ENSRNOG00000008405.
DR   GeneID; 360645; -.
DR   KEGG; rno:360645; -.
DR   UCSC; RGD:1306784; rat.
DR   CTD; 51204; -.
DR   RGD; 1306784; Taco1.
DR   InParanoid; B2RYT9; -.
DR   OrthoDB; 1199273at2759; -.
DR   PhylomeDB; B2RYT9; -.
DR   Reactome; R-RNO-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-RNO-611105; Respiratory electron transport.
DR   Reactome; R-RNO-9707564; Cytoprotection by HMOX1.
DR   PRO; PR:B2RYT9; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Proteomes; UP000234681; Chromosome 10.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0097177; F:mitochondrial ribosome binding; ISO:RGD.
DR   GO; GO:0003729; F:mRNA binding; ISO:RGD.
DR   GO; GO:0019843; F:rRNA binding; ISO:RGD.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISO:RGD.
DR   GO; GO:0061743; P:motor learning; ISO:RGD.
DR   GO; GO:1904959; P:regulation of cytochrome-c oxidase activity; ISO:RGD.
DR   GO; GO:0070129; P:regulation of mitochondrial translation; ISO:RGD.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 3.30.70.980; -; 2.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR002876; Transcrip_reg_TACO1-like.
DR   InterPro; IPR026564; Transcrip_reg_TACO1-like_dom3.
DR   InterPro; IPR029072; YebC-like.
DR   PANTHER; PTHR12532; PTHR12532; 1.
DR   Pfam; PF01709; Transcrip_reg; 1.
DR   SUPFAM; SSF75625; SSF75625; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Activator; Coiled coil; Mitochondrion; Reference proteome;
KW   Translation regulation.
FT   CHAIN           1..295
FT                   /note="Translational activator of cytochrome c oxidase 1"
FT                   /id="PRO_0000388759"
FT   COILED          190..225
FT                   /evidence="ECO:0000255"
FT   MOD_RES         162
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K0Z7"
SQ   SEQUENCE   295 AA;  32754 MW;  4A62E041EBB19A6D CRC64;
     MMSWAAARLT ETAARCFRAR CLGFRVGPWC VSQHENSSYG AAPHRTLRVS AVAFAGHNKW
     SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS SLANILEVCR SKNMPKSTIE
     SALKSEKNKG IYLLYEGRGP GGSSLLIEAL SNSGPKCHLE IKYILNKNGG MMTEGARHFF
     DKKGVVVVGV EDREKKAVNL ERALELAIEA GAEDVREAED EEEEKNLFKF ICDASSLHQV
     RKKLDSLGLC SVSCSLEFIP HSKVQLSEPE LEQAVHLIQA LSNHEDVIHV YDNIE