TACT_RAT
ID TACT_RAT Reviewed; 603 AA.
AC Q5BK49;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=T-cell surface protein tactile;
DE AltName: Full=Cell surface antigen CD96;
DE AltName: Full=T cell-activated increased late expression protein;
DE AltName: CD_antigen=CD96;
DE Flags: Precursor;
GN Name=Cd96;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in adhesive interactions of activated T and
CC NK cells during the late phase of the immune response. Promotes NK
CC cell-target adhesion by interacting with PVR present on target cells.
CC May function at a time after T and NK cells have penetrated the
CC endothelium using integrins and selectins, when they are actively
CC engaging diseased cells and moving within areas of inflammation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PVR (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR EMBL; BC091206; AAH91206.1; -; mRNA.
DR RefSeq; NP_001020203.1; NM_001025032.1.
DR AlphaFoldDB; Q5BK49; -.
DR STRING; 10116.ENSRNOP00000034871; -.
DR GlyGen; Q5BK49; 16 sites.
DR PaxDb; Q5BK49; -.
DR Ensembl; ENSRNOT00000035485; ENSRNOP00000034871; ENSRNOG00000023030.
DR GeneID; 498079; -.
DR KEGG; rno:498079; -.
DR UCSC; RGD:1565249; rat.
DR CTD; 10225; -.
DR RGD; 1565249; Cd96.
DR eggNOG; ENOG502QWNP; Eukaryota.
DR GeneTree; ENSGT00390000003446; -.
DR HOGENOM; CLU_033543_1_0_1; -.
DR InParanoid; Q5BK49; -.
DR OMA; QHGFYCA; -.
DR OrthoDB; 1115066at2759; -.
DR PhylomeDB; Q5BK49; -.
DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR PRO; PR:Q5BK49; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000023030; Expressed in testis and 11 other tissues.
DR Genevisible; Q5BK49; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0002728; P:negative regulation of natural killer cell cytokine production; ISO:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR042381; CD96.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR15317; PTHR15317; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..603
FT /note="T-cell surface protein tactile"
FT /id="PRO_0000313892"
FT TOPO_DOM 22..537
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 559..603
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..132
FT /note="Ig-like V-type 1"
FT DOMAIN 139..245
FT /note="Ig-like V-type 2"
FT DOMAIN 251..356
FT /note="Ig-like C2-type"
FT REGION 359..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 259
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 371
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 425
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 437
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 46..119
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 161..229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 272..336
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 603 AA; 67228 MW; 8D46DDC0AE9B6840 CRC64;
MGRKWTYCVV YAIIQIQFFR GAWEELFNAG DNNVYALPGS DVNLTCQTME KDLMVQMQWS
KVTDEIDMIV VYHPQYGFHY MQGVACESRV AAVETLKDAT KWTLNLRNIS SSLSGKYECS
FTMYPTGTKT IVYNLIVEPY TQDEHNRTIE IETNRTLEIP CFQNTSSEIS PRFTFSWLVE
KDGVEDVLFT YDYHVSNSTA FKGRVGLGAD YGLRLSPVQI QDDGRTFSCF LRISPLKVWK
TSTTVKVFAK PEILMTVENT TMDVLGERVF TCLLKNVFPK ASITWLIDGR LFQGNEEGIY
ITNEEKNSSS GFWELKSVLT RMHNRTSQSN NMTVWCMALS PGPGNKMWNT SSQPITFSLD
SGTAPTKRLP NVTGSTLGAQ TFPDAEVSPT RYLATSSMTI VDENVLTPDP TPQTSNSSMT
TKDVNYSQPS SGTDAKNSSR AASSSDGGSR PFPSTSPPKW LSLPHTSTGP QEPDSAVSWI
PTDAYTSGSS DASLTSHDVI IRTTKEFPDV LTTANGTTKI KHGHVTGITV NKPRDGMSWP
VAVATLLFFC ILLFGLGVRK WCQYQKEIME RPPPFKPPPP PIKYMCIQEP TGRGMPCHEM
EVL
