ID   TAD2B_PONAB             Reviewed;         420 AA.
AC   Q5RBN9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Transcriptional adapter 2-beta;
GN   Name=TADA2B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Coactivates PAX5-dependent transcription together with either
CC       SMARCA4 or GCN5L2. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of
CC       the TFTC-HAT complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; CR858599; CAH90821.1; -; mRNA.
DR   RefSeq; NP_001153252.1; NM_001159780.1.
DR   AlphaFoldDB; Q5RBN9; -.
DR   SMR; Q5RBN9; -.
DR   STRING; 9601.ENSPPYP00000016284; -.
DR   PRIDE; Q5RBN9; -.
DR   GeneID; 100190856; -.
DR   KEGG; pon:100190856; -.
DR   CTD; 93624; -.
DR   eggNOG; KOG0457; Eukaryota.
DR   InParanoid; Q5RBN9; -.
DR   OrthoDB; 812864at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0070461; C:SAGA-type complex; IEA:UniProt.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035065; P:regulation of histone acetylation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00167; SANT; 1.
DR   CDD; cd02335; ZZ_ADA2; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   InterPro; IPR041983; ADA2-like_ZZ.
DR   InterPro; IPR016827; Ada2/TADA2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   PIRSF; PIRSF025024; Transcriptional_adaptor_2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51293; SANT; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..420
FT                   /note="Transcriptional adapter 2-beta"
FT                   /id="PRO_0000313712"
FT   DOMAIN          65..118
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   ZN_FING         4..59
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   REGION          305..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         9
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         12
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         49
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
SQ   SEQUENCE   420 AA;  48470 MW;  89C3365128DF5EBC CRC64;
     MAELGKKYCV YCLAEVSPLR FRCTECQDIE LCPECFSAGA EIGHHRRYHG YQLVDGGRFT
     LWGPEAEGGW TSREEQLLLD AIEQFGFGNW EDMAAHVGAS RTPQEVMEHY VSMYIHGNLG
     KACIPDTIPN RVTDHTCPSG GPLSPSLTTP LPPLDISVAE QQQLGYMPLR DDYEIEYDQD
     AETLISGLSV NYDDDDVEIE LKRAHVDMYV RKLKERQRRK NIARDYNLVP AFLGKDKKEK
     EKALKRKITK EEKELRLKLR PLYQFMSCKE FDDLFENMHK EKMLRAKIRE LQRYRRNGIT
     KMEESAEYEA ARHKREKRKE NKNLAGSKRG KEDGKDSEFA AIENLPGFEL LSDREKVLCS
     SLNLSPARYV TVKTIIIKDH LQKRQGIPSK SRLPSYLDKV LKKRILNFLT ESGWISRDAS