ID   TAD2B_XENLA             Reviewed;         420 AA.
AC   Q6NRB5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Transcriptional adapter 2-beta;
GN   Name=tada2b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional coactivator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC070845; AAH70845.1; -; mRNA.
DR   RefSeq; NP_001084760.1; NM_001091291.1.
DR   AlphaFoldDB; Q6NRB5; -.
DR   SMR; Q6NRB5; -.
DR   BioGRID; 101161; 1.
DR   DNASU; 431795; -.
DR   GeneID; 431795; -.
DR   KEGG; xla:431795; -.
DR   CTD; 431795; -.
DR   Xenbase; XB-GENE-991343; tada2b.L.
DR   OMA; IELCPDC; -.
DR   OrthoDB; 812864at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 431795; Expressed in oocyte and 17 other tissues.
DR   GO; GO:0070461; C:SAGA-type complex; IEA:UniProt.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035065; P:regulation of histone acetylation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00167; SANT; 1.
DR   CDD; cd02335; ZZ_ADA2; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   InterPro; IPR041983; ADA2-like_ZZ.
DR   InterPro; IPR016827; Ada2/TADA2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   PIRSF; PIRSF025024; Transcriptional_adaptor_2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51293; SANT; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..420
FT                   /note="Transcriptional adapter 2-beta"
FT                   /id="PRO_0000313714"
FT   DOMAIN          65..118
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   ZN_FING         4..59
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   REGION          303..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         9
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         12
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         49
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
SQ   SEQUENCE   420 AA;  48445 MW;  0E1C81D591614781 CRC64;
     MADLSKKYCV YCLADVTSLR LRCTECQDIE LCTDCFSAGA EIGNHRRWHG YQLVDGGRFT
     LWGPEAEGGW TSREEQLLLD AIEQFGFGNW EDMAAHVGAS RTPTEVMEHY VTMYIHGNLG
     KACIPDSIPN RVTDHTCPTG GPLSPSLTTP LPTLDLTVAD QQQLGYMPLR DDYEIEFDQE
     AETLISGLSV NYDDDDVEVE LKEAYVDMYV RKLKERQRRK SLARDYNLVP AFLGKDKKEK
     EKPAKRKISK EEKELRLKLR PLYQFMSNKE IEDCFENMHK ERMLRAKIRE LQRYRRNGIT
     KTEESAEYEA ARHKREKRKE NKNIANSKRG REDGKESEFA AIENLAGFEL LSDREKVLCS
     SLNLSPTRYL TVKTIIIKDH LQKRQGIPSK SRLPSYLDKV LKKRILNFLT ESGWISRDAS