TADA1_HUMAN
ID TADA1_HUMAN Reviewed; 335 AA.
AC Q96BN2; A8K4J9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Transcriptional adapter 1;
DE AltName: Full=SPT3-associated factor 42;
DE Short=STAF42;
DE AltName: Full=Transcriptional adapter 1-like protein;
GN Name=TADA1; Synonyms=TADA1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroepithelium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION IN THE STAGA COMPLEX, SUBCELLULAR LOCATION, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11564863; DOI=10.1128/mcb.21.20.6782-6795.2001;
RA Martinez E., Palhan V.B., Tjernberg A., Lymar E.S., Gamper A.M.,
RA Kundu T.K., Chait B.T., Roeder R.G.;
RT "Human STAGA complex is a chromatin-acetylating transcription coactivator
RT that interacts with pre-mRNA splicing and DNA damage-binding factors in
RT vivo.";
RL Mol. Cell. Biol. 21:6782-6795(2001).
CC -!- FUNCTION: Probably involved in transcriptional regulation.
CC -!- SUBUNIT: Component of the STAGA transcription coactivator-HAT complex,
CC at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L,
CC TAD1L, TAF10, TAF12, TRRAP and TAF9. {ECO:0000269|PubMed:11564863}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863}.
CC -!- SIMILARITY: Belongs to the TADA1 family. {ECO:0000305}.
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DR EMBL; AK290964; BAF83653.1; -; mRNA.
DR EMBL; AK291922; BAF84611.1; -; mRNA.
DR EMBL; AL009182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL008639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90778.1; -; Genomic_DNA.
DR EMBL; BC015401; AAH15401.1; -; mRNA.
DR CCDS; CCDS1255.1; -.
DR RefSeq; NP_444281.1; NM_053053.3.
DR PDB; 7KTR; EM; 2.93 A; J=1-335.
DR PDB; 7KTS; EM; 19.09 A; J=1-335.
DR PDBsum; 7KTR; -.
DR PDBsum; 7KTS; -.
DR AlphaFoldDB; Q96BN2; -.
DR SMR; Q96BN2; -.
DR BioGRID; 125555; 54.
DR ComplexPortal; CPX-6802; SAGA complex, KAT2B variant.
DR ComplexPortal; CPX-900; SAGA complex, KAT2A variant.
DR CORUM; Q96BN2; -.
DR IntAct; Q96BN2; 25.
DR MINT; Q96BN2; -.
DR STRING; 9606.ENSP00000356848; -.
DR iPTMnet; Q96BN2; -.
DR PhosphoSitePlus; Q96BN2; -.
DR BioMuta; TADA1; -.
DR DMDM; 74760738; -.
DR EPD; Q96BN2; -.
DR jPOST; Q96BN2; -.
DR MassIVE; Q96BN2; -.
DR MaxQB; Q96BN2; -.
DR PaxDb; Q96BN2; -.
DR PeptideAtlas; Q96BN2; -.
DR PRIDE; Q96BN2; -.
DR ProteomicsDB; 76091; -.
DR Antibodypedia; 34337; 30 antibodies from 14 providers.
DR DNASU; 117143; -.
DR Ensembl; ENST00000367874.5; ENSP00000356848.4; ENSG00000152382.6.
DR GeneID; 117143; -.
DR KEGG; hsa:117143; -.
DR MANE-Select; ENST00000367874.5; ENSP00000356848.4; NM_053053.4; NP_444281.1.
DR UCSC; uc001gdw.4; human.
DR CTD; 117143; -.
DR DisGeNET; 117143; -.
DR GeneCards; TADA1; -.
DR HGNC; HGNC:30631; TADA1.
DR HPA; ENSG00000152382; Low tissue specificity.
DR MIM; 612763; gene.
DR neXtProt; NX_Q96BN2; -.
DR OpenTargets; ENSG00000152382; -.
DR PharmGKB; PA165752724; -.
DR VEuPathDB; HostDB:ENSG00000152382; -.
DR eggNOG; ENOG502QRMT; Eukaryota.
DR GeneTree; ENSGT00390000011644; -.
DR HOGENOM; CLU_071612_0_0_1; -.
DR InParanoid; Q96BN2; -.
DR OMA; NVHFHND; -.
DR OrthoDB; 1528613at2759; -.
DR PhylomeDB; Q96BN2; -.
DR TreeFam; TF324330; -.
DR PathwayCommons; Q96BN2; -.
DR Reactome; R-HSA-3214847; HATs acetylate histones.
DR SignaLink; Q96BN2; -.
DR BioGRID-ORCS; 117143; 175 hits in 1097 CRISPR screens.
DR ChiTaRS; TADA1; human.
DR GenomeRNAi; 117143; -.
DR Pharos; Q96BN2; Tdark.
DR PRO; PR:Q96BN2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96BN2; protein.
DR Bgee; ENSG00000152382; Expressed in secondary oocyte and 178 other tissues.
DR Genevisible; Q96BN2; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005925; C:focal adhesion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000124; C:SAGA complex; IDA:UniProtKB.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
DR GO; GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
DR GO; GO:0035521; P:monoubiquitinated histone deubiquitination; IDA:ComplexPortal.
DR GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; IDA:ComplexPortal.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IC:ComplexPortal.
DR GO; GO:0006282; P:regulation of DNA repair; IC:ComplexPortal.
DR GO; GO:0043484; P:regulation of RNA splicing; IC:ComplexPortal.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR024738; Hfi1/Tada1.
DR PANTHER; PTHR21277; PTHR21277; 1.
DR Pfam; PF12767; SAGA-Tad1; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..335
FT /note="Transcriptional adapter 1"
FT /id="PRO_0000316015"
FT REGION 83..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 198
FT /note="R -> Q (in dbSNP:rs2272792)"
FT /id="VAR_038352"
FT CONFLICT 62
FT /note="F -> S (in Ref. 1; BAF83653)"
FT /evidence="ECO:0000305"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:7KTR"
FT STRAND 109..111
FT /evidence="ECO:0007829|PDB:7KTR"
FT TURN 139..141
FT /evidence="ECO:0007829|PDB:7KTR"
FT STRAND 142..144
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 148..160
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 171..192
FT /evidence="ECO:0007829|PDB:7KTR"
FT TURN 201..203
FT /evidence="ECO:0007829|PDB:7KTR"
FT STRAND 209..211
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 219..229
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 250..264
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 277..286
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 294..305
FT /evidence="ECO:0007829|PDB:7KTR"
FT HELIX 313..330
FT /evidence="ECO:0007829|PDB:7KTR"
SQ SEQUENCE 335 AA; 37382 MW; 1B07D4613107A584 CRC64;
MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL LTQDNVHSHN
DFLLAILTRC QILVSTPDGA GSLPWPGGSA AKPGKPKGKK KLSSVRQKFD HRFQPQNPLS
GAQQFVAKDP QDDDDLKLCS HTMMLPTRGQ LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE
NHLKDILTSV VSRRKAYRLR DGHFKYAFGS NVTPQPYLKN SVVAYNNLIE SPPAFTAPCA
GQNPASHPPP DDAEQQAALL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN
IERIITKLWH PNHEELQQDK VHRQRLAAKE GLLLC
