ID   TADA1_MOUSE             Reviewed;         335 AA.
AC   Q99LM9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Transcriptional adapter 1;
DE   AltName: Full=Transcriptional adapter 1-like protein;
GN   Name=Tada1; Synonyms=Tada1l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably involved in transcriptional regulation.
CC   -!- SUBUNIT: Component of the STAGA transcription coactivator-HAT complex,
CC       at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L,
CC       TAD1L, TAF10, TAF12, TRRAP and TAF9. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TADA1 family. {ECO:0000305}.
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DR   EMBL; AK151132; BAE30140.1; -; mRNA.
DR   EMBL; BC002307; AAH02307.1; -; mRNA.
DR   EMBL; BC027337; AAH27337.1; -; mRNA.
DR   CCDS; CCDS15450.1; -.
DR   RefSeq; NP_084521.1; NM_030245.3.
DR   AlphaFoldDB; Q99LM9; -.
DR   SMR; Q99LM9; -.
DR   BioGRID; 205618; 1.
DR   ComplexPortal; CPX-6803; SAGA complex, KAT2B variant.
DR   ComplexPortal; CPX-920; SAGA complex, KAT2A variant.
DR   IntAct; Q99LM9; 2.
DR   MINT; Q99LM9; -.
DR   STRING; 10090.ENSMUSP00000027846; -.
DR   iPTMnet; Q99LM9; -.
DR   PhosphoSitePlus; Q99LM9; -.
DR   EPD; Q99LM9; -.
DR   MaxQB; Q99LM9; -.
DR   PaxDb; Q99LM9; -.
DR   PeptideAtlas; Q99LM9; -.
DR   PRIDE; Q99LM9; -.
DR   ProteomicsDB; 263241; -.
DR   Antibodypedia; 34337; 30 antibodies from 14 providers.
DR   DNASU; 27878; -.
DR   Ensembl; ENSMUST00000027846; ENSMUSP00000027846; ENSMUSG00000026563.
DR   GeneID; 27878; -.
DR   KEGG; mmu:27878; -.
DR   UCSC; uc007dkm.2; mouse.
DR   CTD; 117143; -.
DR   MGI; MGI:1196415; Tada1.
DR   VEuPathDB; HostDB:ENSMUSG00000026563; -.
DR   eggNOG; ENOG502QRMT; Eukaryota.
DR   GeneTree; ENSGT00390000011644; -.
DR   HOGENOM; CLU_071612_0_0_1; -.
DR   InParanoid; Q99LM9; -.
DR   OMA; NVHFHND; -.
DR   OrthoDB; 1528613at2759; -.
DR   PhylomeDB; Q99LM9; -.
DR   TreeFam; TF324330; -.
DR   BioGRID-ORCS; 27878; 18 hits in 77 CRISPR screens.
DR   ChiTaRS; Tada1; mouse.
DR   PRO; PR:Q99LM9; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q99LM9; protein.
DR   Bgee; ENSMUSG00000026563; Expressed in animal zygote and 264 other tissues.
DR   ExpressionAtlas; Q99LM9; baseline and differential.
DR   Genevisible; Q99LM9; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005925; C:focal adhesion; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0000124; C:SAGA complex; ISO:MGI.
DR   GO; GO:0003713; F:transcription coactivator activity; ISO:MGI.
DR   GO; GO:0043966; P:histone H3 acetylation; ISO:MGI.
DR   GO; GO:0035521; P:monoubiquitinated histone deubiquitination; ISO:MGI.
DR   GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; ISO:MGI.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IC:ComplexPortal.
DR   GO; GO:0006282; P:regulation of DNA repair; IC:ComplexPortal.
DR   GO; GO:0043484; P:regulation of RNA splicing; IC:ComplexPortal.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR024738; Hfi1/Tada1.
DR   PANTHER; PTHR21277; PTHR21277; 1.
DR   Pfam; PF12767; SAGA-Tad1; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..335
FT                   /note="Transcriptional adapter 1"
FT                   /id="PRO_0000316016"
SQ   SEQUENCE   335 AA;  37409 MW;  F3CC5374DA55F918 CRC64;
     MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL LTQDNVHSHN
     DFLLAILTRC QILVSTPEGA GSLPWTGGSA AKPGKPKGKK KLSSVRQKFD HRFQPQNPLS
     GAQQFVAKEP QGDDDLKLCS HTMMLPTRGQ LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE
     NHLKDILTSV VSRRKAYRVR DGHFKYAFGS NVTPQPYLKN SVVAYNNLVE GPPAFSAPCA
     NQSPASQPHP DDAEQQAAFL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN
     IERIIMKLWH PNHEELQQDK VHRQRLAAKE GLLLC