TADA1_RAT
ID TADA1_RAT Reviewed; 335 AA.
AC Q5BJQ7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transcriptional adapter 1;
DE AltName: Full=Transcriptional adapter 1-like protein;
GN Name=Tada1; Synonyms=Tada1l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably involved in transcriptional regulation.
CC -!- SUBUNIT: Component of the STAGA transcription coactivator-HAT complex,
CC at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L,
CC TAD1L, TAF10, TAF12, TRRAP and TAF9. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5BJQ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5BJQ7-2; Sequence=VSP_030756, VSP_030757;
CC -!- SIMILARITY: Belongs to the TADA1 family. {ECO:0000305}.
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DR EMBL; AABR03084751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC091380; AAH91380.1; -; mRNA.
DR RefSeq; NP_001033069.2; NM_001037980.2. [Q5BJQ7-1]
DR AlphaFoldDB; Q5BJQ7; -.
DR SMR; Q5BJQ7; -.
DR STRING; 10116.ENSRNOP00000005090; -.
DR PhosphoSitePlus; Q5BJQ7; -.
DR PaxDb; Q5BJQ7; -.
DR Ensembl; ENSRNOT00000005090; ENSRNOP00000005090; ENSRNOG00000003816. [Q5BJQ7-1]
DR Ensembl; ENSRNOT00000058689; ENSRNOP00000055484; ENSRNOG00000003816. [Q5BJQ7-2]
DR GeneID; 360874; -.
DR KEGG; rno:360874; -.
DR UCSC; RGD:1306774; rat. [Q5BJQ7-1]
DR CTD; 117143; -.
DR RGD; 1306774; Tada1.
DR eggNOG; ENOG502QRMT; Eukaryota.
DR GeneTree; ENSGT00390000011644; -.
DR HOGENOM; CLU_071612_0_0_1; -.
DR InParanoid; Q5BJQ7; -.
DR PhylomeDB; Q5BJQ7; -.
DR TreeFam; TF324330; -.
DR PRO; PR:Q5BJQ7; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000003816; Expressed in thymus and 20 other tissues.
DR ExpressionAtlas; Q5BJQ7; baseline and differential.
DR Genevisible; Q5BJQ7; RN.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0000124; C:SAGA complex; ISO:RGD.
DR GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
DR GO; GO:0043966; P:histone H3 acetylation; ISO:RGD.
DR GO; GO:0035521; P:monoubiquitinated histone deubiquitination; ISO:RGD.
DR GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR024738; Hfi1/Tada1.
DR PANTHER; PTHR21277; PTHR21277; 1.
DR Pfam; PF12767; SAGA-Tad1; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..335
FT /note="Transcriptional adapter 1"
FT /id="PRO_0000316018"
FT VAR_SEQ 1..92
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030756"
FT VAR_SEQ 93..110
FT /note="PGKPKGKKKLSSVRQKFD -> MISSWPSSHAVRFWFLHQ (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030757"
SQ SEQUENCE 335 AA; 37476 MW; 5F8B6304C58A9C95 CRC64;
MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL LTQDNVHSHN
DFLLAILTRC QILVSTPEGA GSLPWTGGSA AKPGKPKGKK KLSSVRQKFD HRFQPQNPLS
GAQQFVAKDP QDDDDLKLCS HTMMLPTRGQ LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE
NHLKDILTSV VSRRKAYRVR DGHFKYAFGS NVTPQPYLKN SVVAYNNLVE GPPAFPAPCA
SQNPASHPHT DDAEQQAAFL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN
IERIIMKLWH PNHEELQQDK VHRQRLAAKE GLLLC
