ID   ABTB1_RAT               Reviewed;         478 AA.
AC   Q5XIU1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 1;
GN   Name=Abtb1 {ECO:0000312|EMBL:AAH83579.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as a mediator of the PTEN growth-suppressive
CC       signaling pathway. May play a role in developmental processes (By
CC       similarity). {ECO:0000250|UniProtKB:Q969K4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969K4}.
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DR   EMBL; BC083579; AAH83579.1; -; mRNA.
DR   RefSeq; NP_001005902.1; NM_001005902.1.
DR   AlphaFoldDB; Q5XIU1; -.
DR   SMR; Q5XIU1; -.
DR   STRING; 10116.ENSRNOP00000021445; -.
DR   SwissPalm; Q5XIU1; -.
DR   PaxDb; Q5XIU1; -.
DR   GeneID; 297432; -.
DR   KEGG; rno:297432; -.
DR   UCSC; RGD:1359363; rat.
DR   CTD; 80325; -.
DR   RGD; 1359363; Abtb1.
DR   VEuPathDB; HostDB:ENSRNOG00000015762; -.
DR   eggNOG; KOG0511; Eukaryota.
DR   HOGENOM; CLU_022885_0_0_1; -.
DR   InParanoid; Q5XIU1; -.
DR   OMA; LQYDYSK; -.
DR   OrthoDB; 871743at2759; -.
DR   PhylomeDB; Q5XIU1; -.
DR   TreeFam; TF329194; -.
DR   PRO; PR:Q5XIU1; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000015762; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q5XIU1; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.30.710.10; -; 2.
DR   InterPro; IPR044515; ABTB1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46231; PTHR46231; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00651; BTB; 2.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00225; BTB; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54695; SSF54695; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50097; BTB; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Cytoplasm; Elongation factor;
KW   Protein biosynthesis; Reference proteome; Repeat.
FT   CHAIN           1..478
FT                   /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT                   1"
FT                   /id="PRO_0000248269"
FT   REPEAT          1..31
FT                   /note="ANK 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          35..64
FT                   /note="ANK 2"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          115..182
FT                   /note="BTB 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          272..346
FT                   /note="BTB 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   COILED          450..478
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   478 AA;  54065 MW;  D5A5553BD87325A3 CRC64;
     MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE LVRYLLANGA
     RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY YDDFLQRLLE QGIHSDVVFV
     VHGKPFRAHR CILGARSTYF ANMLDTKWKG KSVVVLRHPL INPVAFGALL QYLYTGRLDI
     GVEHVSDCER LAKQCQLWDL LDDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRAD
     MALLADCALP PELRGDLGEL PFPCPDGFSS CPDICFRVAD SSFLCHKAFF CGRSDYFRAL
     LDDHFRESEE PVASGDPPVV TLHDISPDIF THVLYYVYSD HTELPPELAY DVLSVADMYL
     LPGLKRLCGR SLAQLLEEDS VVGVWRIAKL FRLARLEDQC TEYMAKVIEK LVEREDFVEA
     VREEAAAVAA RQETDSIPLV DDIRFHVAST VQTYSAIEEA QQQLRALENL LVSIGLDC