ID   BPIA2_RAT               Reviewed;         235 AA.
AC   Q63471;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=BPI fold-containing family A member 2;
DE   AltName: Full=Neonatal submandibular gland protein;
DE   AltName: Full=Parotid secretory protein;
DE            Short=PSP;
DE   Flags: Precursor;
GN   Name=Bpifa2; Synonyms=Psp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Submandibular gland;
RX   PubMed=1370829; DOI=10.1016/s0021-9258(18)45934-0;
RA   Mirels L., Ball W.D.;
RT   "Neonatal rat submandibular gland protein SMG-A and parotid secretory
RT   protein are alternatively regulated members of a salivary protein multigene
RT   family.";
RL   J. Biol. Chem. 267:2679-2687(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley; TISSUE=Submandibular gland;
RX   PubMed=9461541; DOI=10.1042/bj3300437;
RA   Mirels L., Miranda A.J., Ball W.D.;
RT   "Characterization of the rat salivary-gland B1-immunoreactive proteins.";
RL   Biochem. J. 330:437-444(1998).
CC   -!- FUNCTION: Has strong antibacterial activity against P. aeruginosa.
CC       {ECO:0000250|UniProtKB:Q96DR5}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in parotid, submandibular and sublingual
CC       glands. {ECO:0000269|PubMed:9461541}.
CC   -!- DEVELOPMENTAL STAGE: Detected in neonatal submandibular and parotid
CC       gland secretion but not in sublingual gland secretion (at protein
CC       level). In submandibular gland, expressed at high levels in the first
CC       postnatal week, with expression diminishing thereafter.
CC       {ECO:0000269|PubMed:9461541}.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC       {ECO:0000305}.
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DR   EMBL; M83209; AAC06334.1; -; mRNA.
DR   PIR; B42337; B42337.
DR   RefSeq; NP_434695.1; NM_052808.1.
DR   AlphaFoldDB; Q63471; -.
DR   SMR; Q63471; -.
DR   STRING; 10116.ENSRNOP00000018226; -.
DR   PaxDb; Q63471; -.
DR   Ensembl; ENSRNOT00000018226; ENSRNOP00000018226; ENSRNOG00000013540.
DR   GeneID; 50585; -.
DR   KEGG; rno:50585; -.
DR   UCSC; RGD:3431; rat.
DR   CTD; 140683; -.
DR   RGD; 3431; Bpifa2.
DR   eggNOG; ENOG502TE6F; Eukaryota.
DR   GeneTree; ENSGT01020000230460; -.
DR   HOGENOM; CLU_097590_0_0_1; -.
DR   InParanoid; Q63471; -.
DR   OMA; QNELCPR; -.
DR   OrthoDB; 1389938at2759; -.
DR   PhylomeDB; Q63471; -.
DR   TreeFam; TF337052; -.
DR   Reactome; R-RNO-6803157; Antimicrobial peptides.
DR   PRO; PR:Q63471; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Genevisible; Q63471; RN.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0030141; C:secretory granule; IDA:RGD.
DR   GO; GO:0001530; F:lipopolysaccharide binding; ISO:RGD.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   SUPFAM; SSF55394; SSF55394; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..235
FT                   /note="BPI fold-containing family A member 2"
FT                   /id="PRO_0000017186"
FT   DISULFID        161..204
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   235 AA;  24529 MW;  0B36EC779025986E CRC64;
     MFQLGSLVVL CGLLIGTSES LLGDVANAVN NLDILNSPSE AVAQNLNLDV GSLQQATTWP
     SAKDSILETL NKVELGNSNG FTPLNGLLLR VNKFRVLDLQ AGLSSNGKDI DLKLPLVFEI
     SFSLPVIGPT LDVAVSLDLL NSVSVQTNAQ TGLPGVTLGK CSGNTDKISI SLLGRRLPFV
     NRILDGVSGL LTGAVSILLQ NILCPVLQYL LSTMSGSAIQ GLLSNVLTGQ LAVPL