ID   TADBP_CHICK             Reviewed;         414 AA.
AC   Q5ZLN5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=TAR DNA-binding protein 43;
DE            Short=TDP-43;
GN   Name=TARDBP; Synonyms=TDP43; ORFNames=RCJMB04_5g9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Probably involved in transcriptional repression (By
CC       similarity). May play a role in the maintenance of the circadian clock
CC       periodicity (By similarity). {ECO:0000250|UniProtKB:Q13148}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q13148}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13148}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q13148}. Cytoplasm, Stress granule
CC       {ECO:0000250|UniProtKB:Q13148}. Mitochondrion
CC       {ECO:0000250|UniProtKB:Q13148}. Note=Continuously travels in and out of
CC       the nucleus. Localizes to stress granules in response to oxidative
CC       stress. A small subset localizes in mitochondria.
CC       {ECO:0000250|UniProtKB:Q13148}.
CC   -!- DOMAIN: The RRM domains can bind to both DNA and RNA. {ECO:0000250}.
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DR   EMBL; AJ719699; CAG31358.1; -; mRNA.
DR   RefSeq; NP_001026049.1; NM_001030878.1.
DR   AlphaFoldDB; Q5ZLN5; -.
DR   BMRB; Q5ZLN5; -.
DR   SMR; Q5ZLN5; -.
DR   STRING; 9031.ENSGALP00000042272; -.
DR   PaxDb; Q5ZLN5; -.
DR   GeneID; 419453; -.
DR   KEGG; gga:419453; -.
DR   CTD; 23435; -.
DR   VEuPathDB; HostDB:geneid_419453; -.
DR   eggNOG; ENOG502QPQ8; Eukaryota.
DR   InParanoid; Q5ZLN5; -.
DR   OrthoDB; 1425837at2759; -.
DR   PhylomeDB; Q5ZLN5; -.
DR   PRO; PR:Q5ZLN5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR041105; TDP43_N.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF18694; TDP43_N; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Cytoplasm; DNA-binding; Mitochondrion; mRNA processing;
KW   mRNA splicing; Nucleus; Reference proteome; Repeat; Repressor; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..414
FT                   /note="TAR DNA-binding protein 43"
FT                   /id="PRO_0000317416"
FT   DOMAIN          104..200
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          191..262
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          261..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  44590 MW;  17E7114DAB966DB9 CRC64;
     MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MWGVRLVEGI
     LHAPEAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL
     KEYFSTFGEV LMVQVKKDIK TGHSKGFGFV RFTDYETQVK VMSQRHMIDG RWCDCKLPNS
     KQSPDEPLRS RKVFVGRCTE DMTADELQQF FAQYGEVVDV FIPKPFRAFA FVTFADDQVA
     QSLCGEDLII KGISVHISNA EPKHNSNRQL ERGGRFGGNP GGFGNQGGFG NSRGGGGGLG
     NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQPQGNMQ
     REQNQGFSSG NNSYGGSNSG AAIGWGSASN AGSSSGFNGG FGSSMDSKSS GWGM