ID   TADBP_XENTR             Reviewed;         409 AA.
AC   Q28F51; Q6P893;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=TAR DNA-binding protein 43;
DE            Short=TDP-43;
GN   Name=tardbp; Synonyms=tdp43; ORFNames=TGas087d21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in transcriptional repression (By
CC       similarity). May play a role in the maintenance of the circadian clock
CC       periodicity. {ECO:0000250|UniProtKB:Q13148}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q13148}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13148}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q13148}. Cytoplasm, Stress granule
CC       {ECO:0000250|UniProtKB:Q13148}. Mitochondrion
CC       {ECO:0000250|UniProtKB:Q13148}. Note=Continuously travels in and out of
CC       the nucleus. Localizes to stress granules in response to oxidative
CC       stress. A small subset localizes in mitochondria.
CC       {ECO:0000250|UniProtKB:Q13148}.
CC   -!- DOMAIN: The RRM domains can bind to both DNA and RNA. {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH61336.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR762161; CAJ81570.1; -; mRNA.
DR   EMBL; BC061336; AAH61336.1; ALT_INIT; mRNA.
DR   RefSeq; NP_989054.2; NM_203723.2.
DR   AlphaFoldDB; Q28F51; -.
DR   BMRB; Q28F51; -.
DR   SMR; Q28F51; -.
DR   STRING; 8364.ENSXETP00000010789; -.
DR   PaxDb; Q28F51; -.
DR   DNASU; 394651; -.
DR   GeneID; 394651; -.
DR   KEGG; xtr:394651; -.
DR   CTD; 23435; -.
DR   Xenbase; XB-GENE-974453; tardbp.
DR   eggNOG; ENOG502QPQ8; Eukaryota.
DR   HOGENOM; CLU_012062_6_1_1; -.
DR   InParanoid; Q28F51; -.
DR   OrthoDB; 1425837at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006317; Expressed in ovary and 18 other tissues.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR041105; TDP43_N.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF18694; TDP43_N; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Cytoplasm; DNA-binding; Mitochondrion; mRNA processing;
KW   mRNA splicing; Nucleus; Reference proteome; Repeat; Repressor; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..409
FT                   /note="TAR DNA-binding protein 43"
FT                   /id="PRO_0000317417"
FT   DOMAIN          105..200
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          191..262
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          260..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  44430 MW;  F23CFF54F7E602AC CRC64;
     MEMEYIRVAE DENEEPMEIP SEDDGTVLLS TVTAQFPGAC GLRYRNPVNQ CMRGVRLVEG
     ILHAPENGWG NLVYVVNYPK DNKRKMDETD ASSAVKIKRA VTKTSDLIVL GLPWKTTEQD
     LKDYFSTFGE VIMVQVKKDA KTGHSKGFGF VRFADYETQV KVMSQRHMID GRWCDCKLPN
     SKSPDEPMRS RKVFVGRCTE DMSAEELRQF FSQYGEVVDV FIPKPFRAFA FVTFADDQVA
     QSLCGEDLII KGVSVHVSTA EPKHNNNRQL ERGGRFPGPS FGNQGYPNSR PSSGALGNNQ
     GGNMGGGGGM NFGAFSINPA MMAAAQAALQ SSWGMMGMLA SQQNQSGPQG SNQGQGNQQR
     DQPQSFGSNN SYGSNSGAIG WGSPNAGSGS GFNGGFSSSM ESKSSGWGM