BPIA3_HUMAN
ID BPIA3_HUMAN Reviewed; 254 AA.
AC Q9BQP9; Q5JWG8; Q6NZ38;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=BPI fold-containing family A member 3;
DE AltName: Full=Short palate, lung and nasal epithelium carcinoma-associated protein 3;
DE Flags: Precursor;
GN Name=BPIFA3; Synonyms=C20orf71, SPLUNC3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BQP9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BQP9-2; Sequence=VSP_026471;
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC {ECO:0000305}.
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DR EMBL; AL121901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066354; AAH66354.1; -; mRNA.
DR CCDS; CCDS13216.2; -. [Q9BQP9-1]
DR CCDS; CCDS42865.1; -. [Q9BQP9-2]
DR RefSeq; NP_001035904.1; NM_001042439.2. [Q9BQP9-2]
DR RefSeq; NP_848561.2; NM_178466.4. [Q9BQP9-1]
DR AlphaFoldDB; Q9BQP9; -.
DR SMR; Q9BQP9; -.
DR BioGRID; 126167; 1.
DR STRING; 9606.ENSP00000364603; -.
DR GlyGen; Q9BQP9; 1 site.
DR BioMuta; BPIFA3; -.
DR DMDM; 152031690; -.
DR EPD; Q9BQP9; -.
DR jPOST; Q9BQP9; -.
DR MassIVE; Q9BQP9; -.
DR MaxQB; Q9BQP9; -.
DR PaxDb; Q9BQP9; -.
DR PeptideAtlas; Q9BQP9; -.
DR PRIDE; Q9BQP9; -.
DR ProteomicsDB; 78704; -. [Q9BQP9-1]
DR ProteomicsDB; 78705; -. [Q9BQP9-2]
DR Antibodypedia; 25527; 23 antibodies from 11 providers.
DR DNASU; 128861; -.
DR Ensembl; ENST00000375452.3; ENSP00000364601.3; ENSG00000131059.12. [Q9BQP9-2]
DR Ensembl; ENST00000375454.8; ENSP00000364603.3; ENSG00000131059.12. [Q9BQP9-1]
DR GeneID; 128861; -.
DR KEGG; hsa:128861; -.
DR MANE-Select; ENST00000375454.8; ENSP00000364603.3; NM_178466.5; NP_848561.2.
DR UCSC; uc002wyr.5; human. [Q9BQP9-1]
DR CTD; 128861; -.
DR DisGeNET; 128861; -.
DR GeneCards; BPIFA3; -.
DR HGNC; HGNC:16204; BPIFA3.
DR HPA; ENSG00000131059; Tissue enriched (testis).
DR neXtProt; NX_Q9BQP9; -.
DR OpenTargets; ENSG00000131059; -.
DR PharmGKB; PA25782; -.
DR VEuPathDB; HostDB:ENSG00000131059; -.
DR eggNOG; ENOG502T3DV; Eukaryota.
DR GeneTree; ENSGT01020000230460; -.
DR HOGENOM; CLU_101222_0_0_1; -.
DR InParanoid; Q9BQP9; -.
DR OMA; MQLDYGG; -.
DR OrthoDB; 1311318at2759; -.
DR PhylomeDB; Q9BQP9; -.
DR TreeFam; TF337052; -.
DR PathwayCommons; Q9BQP9; -.
DR BioGRID-ORCS; 128861; 12 hits in 1067 CRISPR screens.
DR GenomeRNAi; 128861; -.
DR Pharos; Q9BQP9; Tdark.
DR PRO; PR:Q9BQP9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BQP9; protein.
DR Bgee; ENSG00000131059; Expressed in sperm and 42 other tissues.
DR Genevisible; Q9BQP9; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR032946; Bpifa3.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47736; PTHR47736; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR SUPFAM; SSF55394; SSF55394; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..254
FT /note="BPI fold-containing family A member 3"
FT /id="PRO_0000017187"
FT REGION 233..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..209
FT /evidence="ECO:0000250"
FT VAR_SEQ 93..129
FT /note="SINITNIQLDCGGIQISFHKEWFSANISLEFDLELRP -> R (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026471"
FT VARIANT 41
FT /note="A -> E (in dbSNP:rs17124391)"
FT /id="VAR_049754"
FT VARIANT 136
FT /note="V -> I (in dbSNP:rs3818222)"
FT /id="VAR_049755"
SQ SEQUENCE 254 AA; 28436 MW; E03AFBE138CA073B CRC64;
MMCPLWRLLI FLGLLALPLA PHKQPWPGLA QAHRDNKSTL ARIIAQGLIK HNAESRIQNI
HFGDRLNASA QVAPGLVGWL ISGRKHQQQQ ESSINITNIQ LDCGGIQISF HKEWFSANIS
LEFDLELRPS FDNNIVKMCA HMSIVVEFWL EKDEFGRRDL VIGKCDAEPS SVHVAILTEA
IPPKMNQFLY NLKENLQKVL PHMVESQVCP LIGEILGQLD VKLLKSLIEQ EAAHEPTHHE
TSQPSACQAG ESPS
