ID   TAER_MYCLE              Reviewed;         418 AA.
AC   Q9CD87;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Trans-acting enoyl reductase;
DE            EC=1.3.1.-;
GN   OrderedLocusNames=ML0129;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Involved in the reduction of the double bond between C-4 and
CC       C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated
CC       phenolphthiocerol dimycocerosates (PGL) biosynthesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family. Enoyl
CC       reductase subfamily. {ECO:0000305}.
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DR   EMBL; AL583917; CAC29637.1; -; Genomic_DNA.
DR   PIR; A86925; A86925.
DR   RefSeq; NP_301223.1; NC_002677.1.
DR   RefSeq; WP_010907548.1; NC_002677.1.
DR   AlphaFoldDB; Q9CD87; -.
DR   STRING; 272631.ML0129; -.
DR   EnsemblBacteria; CAC29637; CAC29637; CAC29637.
DR   KEGG; mle:ML0129; -.
DR   PATRIC; fig|272631.5.peg.197; -.
DR   Leproma; ML0129; -.
DR   eggNOG; COG3268; Bacteria.
DR   HOGENOM; CLU_031002_0_2_11; -.
DR   OMA; GPYQLYG; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Oxidoreductase; Reference proteome.
FT   CHAIN           1..418
FT                   /note="Trans-acting enoyl reductase"
FT                   /id="PRO_0000304693"
SQ   SEQUENCE   418 AA;  45140 MW;  1D52D125A4B66576 CRC64;
     MSPDKREFDI VLYGATGFSG KLTAEHLALS ESTARIALAG RSSERLRNVR ALLGPNAQDW
     PLIVADASQP STLEAMAGRA QVVLTTVGPY TRYGLPLVAA CARTGTDYAD LTGELMFCRN
     SIDLHHKQAA ATGARIILAC GFDSVPSDLN VYQLYRRVIE DRTGELCDTD LVLRSFSQRW
     VSGGSVAAYS EAMLTTSNDP EALRLVTDPY TLTTDRDAEP DLGPQPDFPR HRGSDLAPEL
     AGFWTGGFVQ AQFNTRIVRR SNALQNWSYG RQFRYSETMS LGKSWAAPVA SAAVTSVVAG
     AVGLGNKYFN RLPRRVVERV TPKSGTGPSR KTQARGHYTF ETYTTTTTGA RYMATFAHNV
     DAYKSTAGLL AASGLTLALD RDRLSELRGV LTPAAAMGEA LLTRLPSAGV VIGTTRLS