ID   TAER_MYCTU              Reviewed;         418 AA.
AC   P9WGV5; L0TE19; P95139; Q50462; Q50463; Q7D6D4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Trans-acting enoyl reductase;
DE            EC=1.3.1.-;
GN   OrderedLocusNames=Rv2953;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   FUNCTION AS A REDUCTASE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17468241; DOI=10.1128/jb.00169-07;
RA   Simeone R., Constant P., Guilhot C., Daffe M., Chalut C.;
RT   "Identification of the missing trans-acting enoyl reductase required for
RT   phthiocerol dimycocerosate and phenolglycolipid biosynthesis in
RT   Mycobacterium tuberculosis.";
RL   J. Bacteriol. 189:4597-4602(2007).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Involved in the reduction of the double bond between C-4 and
CC       C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated
CC       phenolphthiocerol dimycocerosates (PGL) biosynthesis.
CC       {ECO:0000269|PubMed:17468241}.
CC   -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family. Enoyl
CC       reductase subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA50935.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAA50936.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U00024; AAA50935.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U00024; AAA50936.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL123456; CCP45757.1; -; Genomic_DNA.
DR   PIR; F70669; F70669.
DR   RefSeq; NP_217469.1; NC_000962.3.
DR   RefSeq; WP_003414903.1; NZ_NVQJ01000015.1.
DR   AlphaFoldDB; P9WGV5; -.
DR   STRING; 83332.Rv2953; -.
DR   PaxDb; P9WGV5; -.
DR   DNASU; 887772; -.
DR   GeneID; 887772; -.
DR   KEGG; mtu:Rv2953; -.
DR   TubercuList; Rv2953; -.
DR   eggNOG; COG3268; Bacteria.
DR   OMA; GPYQLYG; -.
DR   PhylomeDB; P9WGV5; -.
DR   BioCyc; MetaCyc:G185E-7207-MON; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071770; P:DIM/DIP cell wall layer assembly; IMP:MTBBASE.
DR   GO; GO:0009247; P:glycolipid biosynthetic process; IMP:MTBBASE.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Lipid biosynthesis; Lipid metabolism; Oxidoreductase; Reference proteome.
FT   CHAIN           1..418
FT                   /note="Trans-acting enoyl reductase"
FT                   /id="PRO_0000304694"
SQ   SEQUENCE   418 AA;  45104 MW;  98FB2577F69F36FF CRC64;
     MSPAEREFDI VLYGATGFSG KLTAEHLAHS GSTARIALAG RSSERLRGVR MMLGPNAADW
     PLILADASQP LTLEAMAARA QVVLTTVGPY TRYGLPLVAA CAKAGTDYAD LTGELMFCRN
     SIDLYHKQAA DTGARIILAC GFDSIPSDLN VYQLYRRSVE DGTGELCDTD LVLRSFSQRW
     VSGGSVATYS EAMRTASSDP EARRLVTDPY TLTTDRGAEP ELGAQPDFLR RPGRDLAPEL
     AGFWTGGFVQ APFNTRIVRR SNALQEWAYG RRFRYSETMS LGKSMAAPIL AAAVTGTVAG
     TIGLGNKYFD RLPRRLVERV TPKPGTGPSR KTQERGHYTF ETYTTTTTGA RYRATFAHNV
     DAYKSTAVLL AQSGLALALD RDRLAELRGV LTPAAAMGDA LLARLPGAGV VMGTTRLS