TAF10_CAEEL
ID TAF10_CAEEL Reviewed; 179 AA.
AC Q95ZS0;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transcription initiation factor TFIID subunit 10 {ECO:0000255|PIRNR:PIRNR017246};
DE AltName: Full=TBP-associated transcription factor family member taf-10 {ECO:0000312|WormBase:K03B4.3b};
GN Name=taf-10 {ECO:0000312|WormBase:K03B4.3b};
GN Synonyms=taf-11 {ECO:0000303|PubMed:11963920};
GN ORFNames=K03B4.3 {ECO:0000312|WormBase:K03B4.3b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=11566890; DOI=10.1093/emboj/20.18.5269;
RA Walker A.K., Rothman J.H., Shi Y., Blackwell T.K.;
RT "Distinct requirements for C.elegans TAF(II)s in early embryonic
RT transcription.";
RL EMBO J. 20:5269-5279(2001).
RN [3] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=11963920; DOI=10.1101/gad.976402;
RA Tora L.;
RT "A unified nomenclature for TATA box binding protein (TBP)-associated
RT factors (TAFs) involved in RNA polymerase II transcription.";
RL Genes Dev. 16:673-675(2002).
CC -!- FUNCTION: The TFIID basal transcription factor complex plays a major
CC role in the initiation of RNA polymerase II (Pol II)-dependent
CC transcription (By similarity). TFIID recognizes and binds promoters via
CC its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of
CC the pre-initiation complex (PIC) (By similarity). The TFIID complex
CC consists of tbp-1 and TBP-associated factors (TAFs), including taf-10
CC (By similarity). Essential for early embryonic development, but not
CC required for transcription of some genes; probably acts via activating
CC transcription initiation by RNA Pol II, as part of the TFIID complex
CC (PubMed:11566890). {ECO:0000250|UniProtKB:Q12962,
CC ECO:0000269|PubMed:11566890}.
CC -!- SUBUNIT: Component of the TFIID basal transcription factor complex,
CC composed of TATA-box-binding protein tbp-1, and a number of TBP-
CC associated factors (TAFs). {ECO:0000250|UniProtKB:Q12962}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PIRNR:PIRNR017246,
CC ECO:0000269|PubMed:11566890}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the 4-cell stage through late
CC gastrulation (at protein level) (PubMed:11566890). May be maternally
CC expressed (PubMed:11566890). {ECO:0000269|PubMed:11566890,
CC ECO:0000303|PubMed:11566890}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes arrested
CC development at 90-100 cells and inhibits differentiation
CC (PubMed:11566890). The two E cell daughters (E2 cells), which form the
CC endoderm, divide abnormally early, immediately after the MS2 cells
CC (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-
CC terminal domain (CTD) is reduced slightly in embryos (PubMed:11566890).
CC Abolishes expression of taf-9, perhaps as a result of altered protein
CC stability (PubMed:11566890). Reduces expression of a range of genes,
CC including let-858, rps-5, hsp16.2, and pes-10, but has little or no
CC effect on expression of cki-2 and sur-5 (PubMed:11566890).
CC {ECO:0000269|PubMed:11566890}.
CC -!- SIMILARITY: Belongs to the TAF10 family. {ECO:0000305}.
CC -!- CAUTION: Throughout PMID:11566890, the gene name taf-11 is used instead
CC of taf-10, based on an earlier nomenclature; readers should be aware to
CC avoid confusion. {ECO:0000303|PubMed:11963920,
CC ECO:0000305|PubMed:11566890}.
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DR EMBL; BX284605; CCD71026.1; -; Genomic_DNA.
DR RefSeq; NP_504260.1; NM_071859.5.
DR AlphaFoldDB; Q95ZS0; -.
DR SMR; Q95ZS0; -.
DR STRING; 6239.K03B4.3b.1; -.
DR PaxDb; Q95ZS0; -.
DR EnsemblMetazoa; K03B4.3b.1; K03B4.3b.1; WBGene00006392.
DR GeneID; 3564983; -.
DR KEGG; cel:CELE_K03B4.3; -.
DR UCSC; K03B4.3a; c. elegans.
DR CTD; 3564983; -.
DR WormBase; K03B4.3b; CE28580; WBGene00006392; taf-10.
DR eggNOG; KOG3423; Eukaryota.
DR GeneTree; ENSGT00390000009368; -.
DR HOGENOM; CLU_1549067_0_0_1; -.
DR InParanoid; Q95ZS0; -.
DR OMA; NTRPPYH; -.
DR OrthoDB; 1478962at2759; -.
DR PhylomeDB; Q95ZS0; -.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00006392; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q95ZS0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0009794; P:regulation of mitotic cell cycle, embryonic; IMP:WormBase.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd07982; TAF10; 1.
DR InterPro; IPR003923; TFIID_30kDa.
DR PANTHER; PTHR21242; PTHR21242; 1.
DR Pfam; PF03540; TFIID_30kDa; 1.
DR PIRSF; PIRSF017246; TFIID_TAF10; 1.
DR PRINTS; PR01443; TFIID30KDSUB.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..179
FT /note="Transcription initiation factor TFIID subunit 10"
FT /id="PRO_0000455416"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 20032 MW; B6A948497CFDC16F CRC64;
MNDPEQYEPS SSTESVLMPP PALPQYFQRP AAAPQVYSTL EPSVQNLRSS LHKPLTGNQQ
QFVQKTLENV QKNPSQDDTH EFINQLADYP PTIPDSVTLH FLKSAGVDGS DPRVTRMISL
AAQKHVSDII LDAMTSARMK GLGQTKKGTK DTKYTLTEEL LDEILKEYGH QNTRPPYHT
