TAF10_DROME
ID TAF10_DROME Reviewed; 167 AA.
AC Q9U5W9; Q9VQG3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transcription initiation factor TFIID subunit 10;
DE AltName: Full=Transcription initiation factor TFIID 24 kDa subunit;
DE Short=TAFII-24;
DE Short=TAFII24;
DE AltName: Full=dTAF(II)24;
GN Name=Taf10 {ECO:0000312|FlyBase:FBgn0028398}; ORFNames=CG2859;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAB55760.2}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:10669741};
RX PubMed=10669741; DOI=10.1128/mcb.20.5.1639-1648.2000;
RA Georgieva S., Kirschner D.B., Jagla T., Nabirochkina E., Hanke S.,
RA Schenkel H., de Lorenzo C., Sinha P., Jagla K., Mechler B., Tora L.;
RT "Two novel Drosophila TAFIIs have homology with human TAFII30 and are
RT differentially regulated during development.";
RL Mol. Cell. Biol. 20:1639-1648(2000).
RN [2] {ECO:0000312|EMBL:CAC08819.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11134347; DOI=10.1128/mcb.21.2.614-623.2001;
RA Hernandez-Hernandez A., Ferrus A.;
RT "Prodos is a conserved transcriptional regulator that interacts with
RT dTAF(II)16 in Drosophila melanogaster.";
RL Mol. Cell. Biol. 21:614-623(2001).
RN [3] {ECO:0000312|EMBL:AAF51210.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAF51210.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5] {ECO:0000312|EMBL:AAM48448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAM48448.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: TFIID is a multimeric protein complex that plays a central
CC role in mediating promoter responses to various activators and
CC repressors. {ECO:0000269|PubMed:10669741}.
CC -!- SUBUNIT: Belongs to the TFIID complex which is composed of TATA binding
CC protein (Tbp) and a number of TBP-associated factors (TAFs). Also a
CC member of the histone acetylase (HAT) complex.
CC {ECO:0000269|PubMed:10669741}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10669741}. Nucleus
CC {ECO:0000269|PubMed:10669741}.
CC -!- TISSUE SPECIFICITY: At embryonic stage 9, highest expression is
CC detected within the ectoderm, ventral chord, and anterior foregut
CC primordium. Later in development preferential expression is in the
CC foregut, proventriculus, and central nervous system. Coexpressed with
CC Taf10b in the lateral epidermis and anal plate.
CC {ECO:0000269|PubMed:10669741}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:10669741}.
CC -!- SIMILARITY: Belongs to the TAF10 family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ243836; CAB55760.2; -; mRNA.
DR EMBL; AJ276419; CAC08819.1; -; mRNA.
DR EMBL; AE014134; AAF51210.1; -; Genomic_DNA.
DR EMBL; AY118419; AAM48448.1; -; mRNA.
DR RefSeq; NP_477463.1; NM_058115.5.
DR AlphaFoldDB; Q9U5W9; -.
DR SMR; Q9U5W9; -.
DR BioGRID; 59692; 14.
DR DIP; DIP-23060N; -.
DR IntAct; Q9U5W9; 9.
DR MINT; Q9U5W9; -.
DR STRING; 7227.FBpp0077401; -.
DR PaxDb; Q9U5W9; -.
DR DNASU; 33469; -.
DR EnsemblMetazoa; FBtr0077717; FBpp0077401; FBgn0028398.
DR GeneID; 33469; -.
DR KEGG; dme:Dmel_CG2859; -.
DR CTD; 6881; -.
DR FlyBase; FBgn0028398; Taf10.
DR VEuPathDB; VectorBase:FBgn0028398; -.
DR eggNOG; KOG3423; Eukaryota.
DR GeneTree; ENSGT00390000009368; -.
DR HOGENOM; CLU_064104_4_1_1; -.
DR InParanoid; Q9U5W9; -.
DR OMA; TMHALKT; -.
DR OrthoDB; 1478962at2759; -.
DR PhylomeDB; Q9U5W9; -.
DR BioGRID-ORCS; 33469; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33469; -.
DR PRO; PR:Q9U5W9; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0028398; Expressed in saliva-secreting gland and 24 other tissues.
DR Genevisible; Q9U5W9; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0000123; C:histone acetyltransferase complex; ISS:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
DR CDD; cd07982; TAF10; 1.
DR InterPro; IPR003923; TFIID_30kDa.
DR PANTHER; PTHR21242; PTHR21242; 1.
DR Pfam; PF03540; TFIID_30kDa; 1.
DR PIRSF; PIRSF017246; TFIID_TAF10; 1.
DR PRINTS; PR01443; TFIID30KDSUB.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..167
FT /note="Transcription initiation factor TFIID subunit 10"
FT /id="PRO_0000118899"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..54
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 167 AA; 18521 MW; 8C8DDCD3BEAEA735 CRC64;
MASDGEDISV TPAESVTSAT DTEEEDIDSP LMQSELHSDE EQPDVEEVPL TTEESEMDEL
IKQLEDYSPT IPDALTMHIL KTAGFCTVDP KIVRLVSVSA QKFISDIAND ALQHCKTRTT
NIQHSSGHSS SKDKKNPKDR KYTLAMEDLV PALADHGITM RKPQYFV
